Developmental and genetic components explain enhanced pulmonary volumes of female peruvian quechua

Bigham, A.; León-Velarde, Fabiola; Rivera Chira, Maria Concepcion; Parra, E.; Brutsaert, T.D.; Kiyamu Tsuchiya, Melisa

dc.contributor.author	Kiyamu Tsuchiya, Melisa
dc.contributor.author	Bigham, A.
dc.contributor.author	Parra, E.
dc.contributor.author	León-Velarde, Fabiola
dc.contributor.author	Rivera Chira, Maria Concepcion
dc.contributor.author	Brutsaert, T.D.
dc.date.accessioned	2022-01-18T19:26:44Z
dc.date.available	2022-01-18T19:26:44Z
dc.date.issued	2012
dc.identifier.uri	https://hdl.handle.net/20.500.12866/10813
dc.description.abstract	High altitude natives have enlarged vital capacities and residual volumes (RV). Because pulmonary volumes are an indication of functionally relevant traits, such as diffusion capacity, the understanding of the factors (genetic/developmental) that influence lung volumes provides insight into the adaptive responses of highlanders. In order to test for the effect of growth and development at high altitude on lung volumes, we obtained forced vital capacities (FVC), RV, and total lung capacities (TLC) for a sample of 65 Peruvian females of mostly Quechua origins (18-34 years) who were sub-divided into two well-matched groups: 1) sea-level born and raised females (BSL, n = 34) from Lima, Peru (150 m), and 2) high-altitude born and raised females (BHA, n = 31) from Cerro de Pasco, Peru (4,338 m). To determine Quechua origins, Native American ancestry proportion (NAAP) for each individual was assessed using a panel of 70 ancestry informative markers. NAAP was similar between groups (BSL = 91.71%; BHA = 89.93%; P = 0.240), and the analysis confirmed predominantly Quechua origins. After adjusting for body size and NAAP, BHA females had significantly higher FVC (3.79 ± 0.06 l; P < 0.001), RV (0.98 ± 0.03 l; P < 0.001) and TLC (4.80 ± 0.07 l; P < 0.001) compared to BSL females (FVC = 3.33 ± 0.05 l; RV = 0.69 ± 0.03 l; TLC = 4.02 ± 0.06 l). NAAP was not associated with FVC (P = 0.352) or TLC (P = 0.506). However, NAAP was positively associated with RV (P = 0.004). In summary, results indicate that developmental exposure to high altitude in females constitutes an important factor for all lung volumes, whereas both genetic and developmental factors seem to be important for RV.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	American Journal of Physical Anthropology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Peru	en_US
dc.subject	Genetics	en_US
dc.subject	Altitude	en_US
dc.subject	Body Size	en_US
dc.subject	Adaptation	en_US
dc.subject	Hypoxia	en_US
dc.subject	Developmental Genetics	en_US
dc.subject	Forced Vital Capacity	en_US
dc.subject	Lung Volume	en_US
dc.subject	Residual Volume	en_US
dc.subject	Total Lung Capacity	en_US
dc.title	Developmental and genetic components explain enhanced pulmonary volumes of female peruvian quechua	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1002/ajpa.22069
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.02
dc.relation.issn	1096-8644