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The association between common physical impairments and dementia in low and middle income countries, and, among people with dementia, their association with cognitive function and disability. A 10/66 Dementia Research Group population-based study

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dc.contributor.author Prince, M.
dc.contributor.author Acosta, D.
dc.contributor.author Ferri, C.P.
dc.contributor.author Guerra Arteaga, Mariella
dc.contributor.author Huang, Y.
dc.contributor.author Jacob, K.S.
dc.contributor.author Jotheeswaran, A.T.
dc.contributor.author Liu, Z.
dc.contributor.author Llibre Rodriguez, J.J.
dc.contributor.author Salas, A.
dc.contributor.author Sosa, A.L.
dc.contributor.author Williams, J.D.
dc.date.accessioned 2022-01-18T19:26:44Z
dc.date.available 2022-01-18T19:26:44Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10816
dc.description.abstract Objective: Chronic physical comorbidity is common in dementia. However, there is an absence of evidence to support good practice guidelines for attention to these problems. We aimed to study the extent of this comorbidity and its impact on cognitive function and disability in population-based studies in low and middle income countries, where chronic diseases and impairments are likely to be both common and undertreated. Methods: A multicentre cross-sectional survey of all over 65 year old residents (n = 15 022) in 11 catchment areas in China, India, Cuba, Dominican Republic, Venezuela, Mexico and Peru. We estimated the prevalence of pain, incontinence, hearing and visual impairments, mobility impairment and undernutrition according to the presence of dementia and its severity, and, among those with dementia, the independent contribution of these impairments to cognitive function and disability, adjusting for age, gender, education and dementia severity. Results: Incontinence, hearing impairment, mobility impairment and undernutrition were consistently linearly associated with the presence of dementia and its severity across regions. Among people with dementia, incontinence, hearing impairment and mobility impairment were independently associated with disability in all regions while the contributions of pain, visual impairment and undernutrition were inconsistent. Only hearing impairment made a notable independent contribution to cognitive impairment. Conclusions: There is an urgent need for clinical trials of the feasibility, efficacy and cost-effectiveness of regular physical health checks and remediation of identified pathologies, given the considerable comorbidity identified in our population based studies, and the strong evidence for independent impact upon functioning. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries International Journal of Geriatric Psychiatry
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Aged, 80 and over en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject article en_US
dc.subject Cross-Sectional Studies en_US
dc.subject major clinical study en_US
dc.subject population research en_US
dc.subject disease severity en_US
dc.subject Socioeconomic Factors en_US
dc.subject comorbidity en_US
dc.subject prevalence en_US
dc.subject China en_US
dc.subject socioeconomics en_US
dc.subject malnutrition en_US
dc.subject clinical assessment en_US
dc.subject cost effectiveness analysis en_US
dc.subject Developing Countries en_US
dc.subject Comorbidity en_US
dc.subject Mexico en_US
dc.subject Regression Analysis en_US
dc.subject Dominican Republic en_US
dc.subject Venezuela en_US
dc.subject Cuba en_US
dc.subject dementia en_US
dc.subject Dementia en_US
dc.subject India en_US
dc.subject health care en_US
dc.subject visual impairment en_US
dc.subject disability en_US
dc.subject Cognition en_US
dc.subject Disabled Persons en_US
dc.subject Hearing disorders en_US
dc.subject incontinence en_US
dc.subject Nutrition disorders en_US
dc.subject pain en_US
dc.subject patient mobility en_US
dc.subject physical disease en_US
dc.subject Urinary incontinence en_US
dc.subject Vision disorders en_US
dc.title The association between common physical impairments and dementia in low and middle income countries, and, among people with dementia, their association with cognitive function and disability. A 10/66 Dementia Research Group population-based study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/gps.2558
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.24
dc.relation.issn 1099-1166


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