Universidad Peruana Cayetano Heredia

Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1

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dc.contributor.author Talledo Albujar, Michael John
dc.contributor.author López, G.
dc.contributor.author Huyghe, J.R.
dc.contributor.author Verdonck, K.
dc.contributor.author González Lagos, Elsa Violeta
dc.contributor.author Clark, D.
dc.contributor.author Vanham, G.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author van Camp, G.
dc.contributor.author van Laer, L.
dc.date.accessioned 2022-01-18T19:26:44Z
dc.date.available 2022-01-18T19:26:44Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10820
dc.description.abstract The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive disease causing paraparesis of the lower limbs. Only a minority of persons infected with HTLV-1 develop HAM/TSP. Universal susceptibility factors for HAM/TSP are not known. The viral genotype is similar in asymptomatic carriers and HAM/TSP patients. High proviral load has been associated consistently with HAM/TSP, but this factor does not explain fully the presence of disease in HTLV-1-infected subjects. Most likely, host genetic factors will play an important role in HAM/TSP development. A two-stage case-control study was carried out to evaluate the association between HAM/TSP and candidate single nucleotide polymorphisms (SNPs) from 45 genes in addition to six human leukocyte antigen (HLA) alleles. Ancestry-informative markers were used to correct for population stratification. Several SNPs belonging to NFKB1A and NKG2D showed a trend of association in both stages. The fact that the direction of the association observed in the first stage was the same in the second stage suggests that NFKB1A and NKG2D may be implicated in the development of HAM/TSP. Further replication studies in independent HTLV-1 patient groups should validate further these associations. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Journal of Medical Virology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans|Peru en_US
dc.subject Major Clinical Study en_US
dc.subject Genotype en_US
dc.subject Human Tissue en_US
dc.subject HTLV 1 Associated Myelopathy en_US
dc.subject Human T-Lymphotropic Virus 1 en_US
dc.subject Paraparesis Tropical Spastic en_US
dc.subject Polymorphism Single Nucleotide en_US
dc.subject Gene en_US
dc.subject Genetic Association en_US
dc.subject Biological Markers en_US
dc.subject Human T Cell Leukemia Virus Infection en_US
dc.subject Viral Load en_US
dc.subject Chromosome Mapping en_US
dc.subject Genetic Susceptibility en_US
dc.subject Genetic Predisposition To Disease en_US
dc.subject Spastic Paraplegia en_US
dc.subject Genetic Association Studies en_US
dc.subject HLA Antigen en_US
dc.subject Human T-Cell Lymphotropic Virus 1 en_US
dc.subject Natural Killer Cell Receptor NKG2D en_US
dc.subject NF-Kappa B P50 Subunit en_US
dc.subject NFKB1A Gene en_US
dc.subject NK Cell Lectin-Like Receptor Subfamily K en_US
dc.subject Proviruses en_US
dc.subject Spinal Cord Diseases en_US
dc.subject Tropical Spastic Paraparesis en_US
dc.title Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1 en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/jmv.22255
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.02
dc.relation.issn 1096-9071


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