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Cross-reactive antibodies to target proteins are dependent upon oligomannose glycosylated epitopes in HTLV-1 associated neurological disease

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dc.contributor.author Lee, S.
dc.contributor.author Shin, Y.
dc.contributor.author Clark, D.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Levin, M.C.
dc.date.accessioned 2022-01-18T19:26:45Z
dc.date.available 2022-01-18T19:26:45Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10827
dc.description.abstract Our lab recently identified a cross-reactive antibody response between human T-lymphotropic virus type-1- p24-(gag) (HTLV-1-p24-(gag)) and peroxiredoxin-1 (PrX- 1) as potentially contributing to the pathogenesis of HTLV-1 associated neurological disease via molecular mimicry. These targets proteins were glycosylated, yet the glycan side chains immunoreactive with the immunoglobulins were unknown. Using a combination of lectin isolation and serial enzymatic deglycosylation of glycoproteins, we determined that the immunoreactive epitopes contained branched oligomannose side chains. These data suggest that posttranslational glycosylation specifically related to oligomannose immunoreactivity to both the infecting and host antigens may contribute to molecular mimicry and be important in the pathogenesis of HTLV-1 associated neurological disease. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Journal of Clinical Immunology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Controlled Study en_US
dc.subject Clinical |Human T-Lymphotropic Virus 1 en_US
dc.subject Paraparesis Tropical Spastic en_US
dc.subject Cell Line en_US
dc.subject Immunoglobulin G en_US
dc.subject Cross Reactions en_US
dc.subject Oligosaccharides en_US
dc.subject HTLV-1 en_US
dc.subject Epitope en_US
dc.subject Immunoreactivity en_US
dc.subject Antigen Structure en_US
dc.subject Deglycosylation en_US
dc.subject Epitopes en_US
dc.subject Gag Protein en_US
dc.subject Glycosylation en_US
dc.subject Lectin en_US
dc.subject Mannose Oligosaccharide en_US
dc.subject Molecular Mimicry en_US
dc.subject Nervous System Diseases en_US
dc.subject Peroxiredoxins en_US
dc.subject Protein Processing Post-Translational en_US
dc.subject Protein Targeting en_US
dc.subject Retroviridae Proteins Oncogenic en_US
dc.title Cross-reactive antibodies to target proteins are dependent upon oligomannose glycosylated epitopes in HTLV-1 associated neurological disease en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s10875-012-9652-9
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 1573-2592

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