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High serum zinc and serum testosterone levels were associated with excessive erythrocytosis in men at high altitudes.

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dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.contributor.author Tapia Aguirre, Vilma Lucrecia
dc.contributor.author Gasco Tantachuco, Manuel Enrique
dc.contributor.author Rubio, Julio
dc.contributor.author Gonzales-Castañeda, Cynthia
dc.date.accessioned 2022-01-18T19:26:45Z
dc.date.available 2022-01-18T19:26:45Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10834
dc.description.abstract Chronic mountain sickness (CMS), a lack of adaptation to altitude characterized by excessive erythrocytosis (EE), is a health problem associated with life at high altitude. The erythropoietic process is regulated by both erythropoietin and testosterone. Zinc (Zn) is known to be related with testosterone and hemoglobin levels; meanwhile, nitric oxide was also associated with adaptation to high altitude. The aim of this study was to determine the relationship of hemoglobin and CMS score with serum levels of zinc, total testosterone (TT), calculated free testosterone (cFT), bioavailable testosterone (BAT), hemoglobin, and nitric oxide in men at high altitude with or without EE. Men residing in Lima (150 m) and Cerro de Pasco (4,340 m), Peru, were divided into three groups: (1) low altitude, (2) high altitude without EE (hemoglobin < 21 g/dl), and (3) high altitude with EE (hemoglobin ≥ 21 g/dl). Adjusted multivariable regression models showed that serum testosterone (total or free) and Zn levels were independently correlated with increased hemoglobin levels. Similarly, hemoglobin was positively related with signs/symptoms of CMS; however, both increased the serum Zn and the nitric oxide levels correlated with reduced risk for signs/symptoms of CMS. In conclusion, higher serum testosterone levels and Zn levels were associated with EE, and low scores of signs/symptoms of CMS were associated with higher Zn and nitric oxide levels. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Endocrine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Adaptation Physiological en_US
dc.subject Chronic Disease en_US
dc.subject Testosterone en_US
dc.title High serum zinc and serum testosterone levels were associated with excessive erythrocytosis in men at high altitudes. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s12020-011-9482-1
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 1559-0100


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