Universidad Peruana Cayetano Heredia

Immunohistochemical Expression of p16, p21, p27 and Cyclin D1 in Oral Nevi and Melanoma

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dc.contributor.author de Andrade, B.A.B.
dc.contributor.author León, J.E.
dc.contributor.author Carlos, R.
dc.contributor.author Delgado-Azañero, W.
dc.contributor.author Mosqueda-Taylor, A.
dc.contributor.author de Almeida, O.P.
dc.date.accessioned 2022-01-18T19:26:45Z
dc.date.available 2022-01-18T19:26:45Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10835
dc.description.abstract The acquisition of abnormalities at G1/S is considered a crucial step in the genesis and progression of melanoma. The expression of cell cycle regulators has also been used in various neoplasms as an adjunct to diagnosis. The aim of this study was to compare the expression of p16, p21, p27 and cyclin D1 in oral nevi and melanomas. Expression of these cell cycle regulatory proteins was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas. p16 and p27 were highly expressed in intramucosal nevi, whereas p21 and cyclin D1 expression was higher in oral melanomas. The results indicate that p21 and cyclin D1 may be involved in the development of oral melanomas, and eventually they may be useful in the differential diagnoses of oral benign and malignant melanocytic lesions. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Head and Neck Pathology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject metabolism en_US
dc.subject tumor marker en_US
dc.subject Tumor Markers, Biological en_US
dc.subject Immunohistochemistry en_US
dc.subject Melanoma en_US
dc.subject Mouth Neoplasms en_US
dc.subject Oral melanoma en_US
dc.subject Oral nevi en_US
dc.subject biosynthesis en_US
dc.subject CCND1 protein, |CDKN1A protein, |Cell cycle en_US
dc.subject Cyclin D1 en_US
dc.subject cyclin dependent kinase inhibitor 1A en_US
dc.subject cyclin dependent kinase inhibitor 1B en_US
dc.subject Cyclin-Dependent Kinase Inhibitor p21 en_US
dc.subject Cyclin-Dependent Kinase Inhibitor p27 en_US
dc.subject mouth tumor en_US
dc.subject Neoplasm Proteins en_US
dc.subject Nevus en_US
dc.subject P16 protein, |tumor protein en_US
dc.title Immunohistochemical Expression of p16, p21, p27 and Cyclin D1 in Oral Nevi and Melanoma en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s12105-012-0334-y
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.21
dc.relation.issn 1936-0568


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