Amazonian malaria: Asymptomatic human reservoirs, diagnostic challenges, environmentally driven changes in mosquito vector populations, and the mandate for sustainable control strategies

Vinetz, Joseph Michael; Moreno, M.; Conn, J.E.; da Silva-Nunes, M.; Gamboa Vilela, Dionicia Baziliza; Ferreira, M.U.; Abeles, S.

dc.contributor.author	da Silva-Nunes, M.
dc.contributor.author	Moreno, M.
dc.contributor.author	Conn, J.E.
dc.contributor.author	Gamboa Vilela, Dionicia Baziliza
dc.contributor.author	Abeles, S.
dc.contributor.author	Vinetz, Joseph Michael
dc.contributor.author	Ferreira, M.U.
dc.date.accessioned	2022-01-18T19:26:45Z
dc.date.available	2022-01-18T19:26:45Z
dc.date.issued	2012
dc.identifier.uri	https://hdl.handle.net/20.500.12866/10838
dc.description.abstract	Across the Americas and the Caribbean, nearly 561,000 slide-confirmed malaria infections were reported officially in 2008. The nine Amazonian countries accounted for 89% of these infections; Brazil and Peru alone contributed 56% and 7% of them, respectively. Local populations of the relatively neglected parasite Plasmodium vivax, which currently accounts for 77% of the regional malaria burden, are extremely diverse genetically and geographically structured. At a time when malaria elimination is placed on the public health agenda of several endemic countries, it remains unclear why malaria proved so difficult to control in areas of relatively low levels of transmission such as the Amazon Basin. We hypothesize that asymptomatic parasite carriage and massive environmental changes that affect vector abundance and behavior are major contributors to malaria transmission in epidemiologically diverse areas across the Amazon Basin. Here we review available data supporting this hypothesis and discuss their implications for current and future malaria intervention policies in the region. Given that locally generated scientific evidence is urgently required to support malaria control interventions in Amazonia, we briefly describe the aims of our current field-oriented malaria research in rural villages and gold-mining enclaves in Peru and a recently opened agricultural settlement in Brazil.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Acta Tropica
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Humans	en_US
dc.subject	Peru	en_US
dc.subject	article	en_US
dc.subject	Animals	en_US
dc.subject	non\|polymerase chain reaction	en_US
dc.subject	abundance	en_US
dc.subject	Amazon Basin	en_US
dc.subject	Amazonia	en_US
dc.subject	Anopheles	en_US
dc.subject	asymptomatic infection	en_US
dc.subject	bed net	en_US
dc.subject	Brazil	en_US
dc.subject	Carrier State	en_US
dc.subject	Central America	en_US
dc.subject	cluster analysis	en_US
dc.subject	Communicable Disease Control	en_US
dc.subject	Culicidae	en_US
dc.subject	cyhalothrin	en_US
dc.subject	diagnostic test	en_US
dc.subject	Diagnostics	en_US
dc.subject	disease carrier	en_US
dc.subject	disease control	en_US
dc.subject	disease transmission	en_US
dc.subject	Disease Transmission, Infectious	en_US
dc.subject	Disease Vectors	en_US
dc.subject	Ecology	en_US
dc.subject	endemic disease	en_US
dc.subject	endemism	en_US
dc.subject	Environment	en_US
dc.subject	environmental change	en_US
dc.subject	epidemiology	en_US
dc.subject	gene deletion	en_US
dc.subject	geographic distribution	en_US
dc.subject	health care policy	en_US
dc.subject	Health Policy	en_US
dc.subject	histidine rich protein 2	en_US
dc.subject	HRP2 gene	en_US
dc.subject	HRP3 gene	en_US
dc.subject	infectious disease	en_US
dc.subject	Insecticide-Treated Bednets	en_US
dc.subject	intervention study	en_US
dc.subject	malaria	en_US
dc.subject	Malaria	en_US
dc.subject	malaria control	en_US
dc.subject	marker gene	en_US
dc.subject	mass screening	en_US
dc.subject	medical research	en_US
dc.subject	microsatellite marker	en_US
dc.subject	mining	en_US
dc.subject	Mosquito Control	en_US
dc.subject	parasite	en_US
dc.subject	parasite antigen	en_US
dc.subject	parasite transmission	en_US
dc.subject	parasite virulence	en_US
dc.subject	Plasmodium	en_US
dc.subject	Plasmodium vivax	en_US
dc.subject	Population Density	en_US
dc.subject	population ecology	en_US
dc.subject	population research	en_US
dc.subject	protein determination	en_US
dc.subject	protist life cycle stage	en_US
dc.subject	public health	en_US
dc.subject	rural area	en_US
dc.subject	unclassified drug	en_US
dc.subject	Vector biology	en_US
dc.subject	vector control	en_US
dc.title	Amazonian malaria: Asymptomatic human reservoirs, diagnostic challenges, environmentally driven changes in mosquito vector populations, and the mandate for sustainable control strategies	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.actatropica.2011.10.001
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1873-6254