Universidad Peruana Cayetano Heredia

Amazonian malaria: Asymptomatic human reservoirs, diagnostic challenges, environmentally driven changes in mosquito vector populations, and the mandate for sustainable control strategies

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dc.contributor.author da Silva-Nunes, M.
dc.contributor.author Moreno, M.
dc.contributor.author Conn, J.E.
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Abeles, S.
dc.contributor.author Vinetz, Joseph Michael
dc.contributor.author Ferreira, M.U.
dc.date.accessioned 2022-01-18T19:26:45Z
dc.date.available 2022-01-18T19:26:45Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10838
dc.description.abstract Across the Americas and the Caribbean, nearly 561,000 slide-confirmed malaria infections were reported officially in 2008. The nine Amazonian countries accounted for 89% of these infections; Brazil and Peru alone contributed 56% and 7% of them, respectively. Local populations of the relatively neglected parasite Plasmodium vivax, which currently accounts for 77% of the regional malaria burden, are extremely diverse genetically and geographically structured. At a time when malaria elimination is placed on the public health agenda of several endemic countries, it remains unclear why malaria proved so difficult to control in areas of relatively low levels of transmission such as the Amazon Basin. We hypothesize that asymptomatic parasite carriage and massive environmental changes that affect vector abundance and behavior are major contributors to malaria transmission in epidemiologically diverse areas across the Amazon Basin. Here we review available data supporting this hypothesis and discuss their implications for current and future malaria intervention policies in the region. Given that locally generated scientific evidence is urgently required to support malaria control interventions in Amazonia, we briefly describe the aims of our current field-oriented malaria research in rural villages and gold-mining enclaves in Peru and a recently opened agricultural settlement in Brazil. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Acta Tropica
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject article en_US
dc.subject Animals en_US
dc.subject non|polymerase chain reaction en_US
dc.subject abundance en_US
dc.subject Amazon Basin en_US
dc.subject Amazonia en_US
dc.subject Anopheles en_US
dc.subject asymptomatic infection en_US
dc.subject bed net en_US
dc.subject Brazil en_US
dc.subject Carrier State en_US
dc.subject Central America en_US
dc.subject cluster analysis en_US
dc.subject Communicable Disease Control en_US
dc.subject Culicidae en_US
dc.subject cyhalothrin en_US
dc.subject diagnostic test en_US
dc.subject Diagnostics en_US
dc.subject disease carrier en_US
dc.subject disease control en_US
dc.subject disease transmission en_US
dc.subject Disease Transmission, Infectious en_US
dc.subject Disease Vectors en_US
dc.subject Ecology en_US
dc.subject endemic disease en_US
dc.subject endemism en_US
dc.subject Environment en_US
dc.subject environmental change en_US
dc.subject epidemiology en_US
dc.subject gene deletion en_US
dc.subject geographic distribution en_US
dc.subject health care policy en_US
dc.subject Health Policy en_US
dc.subject histidine rich protein 2 en_US
dc.subject HRP2 gene en_US
dc.subject HRP3 gene en_US
dc.subject infectious disease en_US
dc.subject Insecticide-Treated Bednets en_US
dc.subject intervention study en_US
dc.subject malaria en_US
dc.subject Malaria en_US
dc.subject malaria control en_US
dc.subject marker gene en_US
dc.subject mass screening en_US
dc.subject medical research en_US
dc.subject microsatellite marker en_US
dc.subject mining en_US
dc.subject Mosquito Control en_US
dc.subject parasite en_US
dc.subject parasite antigen en_US
dc.subject parasite transmission en_US
dc.subject parasite virulence en_US
dc.subject Plasmodium en_US
dc.subject Plasmodium vivax en_US
dc.subject Population Density en_US
dc.subject population ecology en_US
dc.subject population research en_US
dc.subject protein determination en_US
dc.subject protist life cycle stage en_US
dc.subject public health en_US
dc.subject rural area en_US
dc.subject unclassified drug en_US
dc.subject Vector biology en_US
dc.subject vector control en_US
dc.title Amazonian malaria: Asymptomatic human reservoirs, diagnostic challenges, environmentally driven changes in mosquito vector populations, and the mandate for sustainable control strategies en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.actatropica.2011.10.001
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1873-6254


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