dc.contributor.author |
Torres-Romero, D. |
|
dc.contributor.author |
Jiménez, I.A. |
|
dc.contributor.author |
Rojas, R. |
|
dc.contributor.author |
Gilman, Robert Hugh |
|
dc.contributor.author |
López, M. |
|
dc.contributor.author |
Bazzocchi, I.L. |
|
dc.date.accessioned |
2022-01-18T19:26:45Z |
|
dc.date.available |
2022-01-18T19:26:45Z |
|
dc.date.issued |
2011 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/10842 |
|
dc.description.abstract |
In the present study, we report four new dihydro-β-agarofuran sesquiterpenes (1-4), which were isolated from the leaves of Celastrus vulcanicola, in addition to five derivatives (5-9). Their stereostructures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques, X-ray studies, chemical correlations and biogenetic means. Compounds 1-9 and the previously reported sesquiterpenes 10-25 have been tested as potential antimycobacterial agents against sensitive and resistant Mycobacterium tuberculosis strains. 1α-Acetoxy-6β,9β-dibenzoyloxy-dihydro- β-agarofuran (20) exhibited antituberculosis activity against the MDR TB strain with a MIC value of 6.2 μg/mL, comparable to or better than isoniazid or rifampin, two of the best first-line drugs commonly used in the treatment of TB. The structure-activity relationship is discussed. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Bioorganic and Medicinal Chemistry |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
article |
en_US |
dc.subject |
controlled study |
en_US |
dc.subject |
non|unclassified drug |
en_US |
dc.subject |
rifampicin |
en_US |
dc.subject |
Mycobacterium tuberculosis |
en_US |
dc.subject |
Antitubercular Agents |
en_US |
dc.subject |
isoniazid |
en_US |
dc.subject |
multidrug resistant tuberculosis |
en_US |
dc.subject |
tuberculostatic agent |
en_US |
dc.subject |
Models, Molecular |
en_US |
dc.subject |
Drug Resistance, Multiple, Bacterial |
en_US |
dc.subject |
antibiotic sensitivity |
en_US |
dc.subject |
minimum inhibitory concentration |
en_US |
dc.subject |
bacterial strain |
en_US |
dc.subject |
1 acetoxy 9 benzoyloxy 8 (dihydroxy 3 phenyl)propanoiloxy 4,6 dihydroxydihydro beta agarofuran |
en_US |
dc.subject |
1,4,6,8,9 pentahydroxydihydro beta agarofuran |
en_US |
dc.subject |
1,6 diacetoxy 9 benzoyloxy 4,8 dihydroxydihydro beta agarofuran |
en_US |
dc.subject |
1,6,8 triacetoxy 4,9 dihydroxydihydro beta agarofuran |
en_US |
dc.subject |
1,6,8,9 tetraacetoxy 4 hydroxydihydro beta agarofuran |
en_US |
dc.subject |
1,8 diacetoxy 4,6,9 trihydroxydihydro beta agarofuran |
en_US |
dc.subject |
1,8 diacetoxy 9 benzoyloxy 6 hydroxydihydro beta agarofuran |
en_US |
dc.subject |
1,8 diacetoxy 9 benzoyloxy 6 nicotinoyloxydihydro beta agarofuran |
en_US |
dc.subject |
1,8 diacetoxy 9,6 dibenzoyloxy 4 hydroxydihydro beta agarofuran |
en_US |
dc.subject |
1alpha acetoxy 6beta,9beta dibenzoyloxydihydro beta agarofuran |
en_US |
dc.subject |
antimycobacterial agent |
en_US |
dc.subject |
Celastrus |
en_US |
dc.subject |
Celastrus vulcanicola |
en_US |
dc.subject |
Crystallography, X-Ray |
en_US |
dc.subject |
dihydro beta agarofuran sesquiterpene derivative |
en_US |
dc.subject |
drug isolation |
en_US |
dc.subject |
Furans |
en_US |
dc.subject |
Molecular Structure |
en_US |
dc.subject |
Multidrug-resistant |
en_US |
dc.subject |
plant leaf |
en_US |
dc.subject |
sesquiterpene derivative |
en_US |
dc.subject |
Sesquiterpenes |
en_US |
dc.subject |
structure activity relation |
en_US |
dc.subject |
Structure-Activity Relationship |
en_US |
dc.title |
Dihydro-β-agarofuran sesquiterpenes isolated from Celastrus vulcanicola as potential anti-Mycobacterium tuberculosis multidrug-resistant agents |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1016/j.bmc.2011.02.034 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.01.06 |
|
dc.relation.issn |
1464-3391 |
|