Universidad Peruana Cayetano Heredia

Dihydro-β-agarofuran sesquiterpenes isolated from Celastrus vulcanicola as potential anti-Mycobacterium tuberculosis multidrug-resistant agents

Mostrar el registro sencillo del ítem

dc.contributor.author Torres-Romero, D.
dc.contributor.author Jiménez, I.A.
dc.contributor.author Rojas, R.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author López, M.
dc.contributor.author Bazzocchi, I.L.
dc.date.accessioned 2022-01-18T19:26:45Z
dc.date.available 2022-01-18T19:26:45Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10842
dc.description.abstract In the present study, we report four new dihydro-β-agarofuran sesquiterpenes (1-4), which were isolated from the leaves of Celastrus vulcanicola, in addition to five derivatives (5-9). Their stereostructures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques, X-ray studies, chemical correlations and biogenetic means. Compounds 1-9 and the previously reported sesquiterpenes 10-25 have been tested as potential antimycobacterial agents against sensitive and resistant Mycobacterium tuberculosis strains. 1α-Acetoxy-6β,9β-dibenzoyloxy-dihydro- β-agarofuran (20) exhibited antituberculosis activity against the MDR TB strain with a MIC value of 6.2 μg/mL, comparable to or better than isoniazid or rifampin, two of the best first-line drugs commonly used in the treatment of TB. The structure-activity relationship is discussed. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Bioorganic and Medicinal Chemistry
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject article en_US
dc.subject controlled study en_US
dc.subject non|unclassified drug en_US
dc.subject rifampicin en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Antitubercular Agents en_US
dc.subject isoniazid en_US
dc.subject multidrug resistant tuberculosis en_US
dc.subject tuberculostatic agent en_US
dc.subject Models, Molecular en_US
dc.subject Drug Resistance, Multiple, Bacterial en_US
dc.subject antibiotic sensitivity en_US
dc.subject minimum inhibitory concentration en_US
dc.subject bacterial strain en_US
dc.subject 1 acetoxy 9 benzoyloxy 8 (dihydroxy 3 phenyl)propanoiloxy 4,6 dihydroxydihydro beta agarofuran en_US
dc.subject 1,4,6,8,9 pentahydroxydihydro beta agarofuran en_US
dc.subject 1,6 diacetoxy 9 benzoyloxy 4,8 dihydroxydihydro beta agarofuran en_US
dc.subject 1,6,8 triacetoxy 4,9 dihydroxydihydro beta agarofuran en_US
dc.subject 1,6,8,9 tetraacetoxy 4 hydroxydihydro beta agarofuran en_US
dc.subject 1,8 diacetoxy 4,6,9 trihydroxydihydro beta agarofuran en_US
dc.subject 1,8 diacetoxy 9 benzoyloxy 6 hydroxydihydro beta agarofuran en_US
dc.subject 1,8 diacetoxy 9 benzoyloxy 6 nicotinoyloxydihydro beta agarofuran en_US
dc.subject 1,8 diacetoxy 9,6 dibenzoyloxy 4 hydroxydihydro beta agarofuran en_US
dc.subject 1alpha acetoxy 6beta,9beta dibenzoyloxydihydro beta agarofuran en_US
dc.subject antimycobacterial agent en_US
dc.subject Celastrus en_US
dc.subject Celastrus vulcanicola en_US
dc.subject Crystallography, X-Ray en_US
dc.subject dihydro beta agarofuran sesquiterpene derivative en_US
dc.subject drug isolation en_US
dc.subject Furans en_US
dc.subject Molecular Structure en_US
dc.subject Multidrug-resistant en_US
dc.subject plant leaf en_US
dc.subject sesquiterpene derivative en_US
dc.subject Sesquiterpenes en_US
dc.subject structure activity relation en_US
dc.subject Structure-Activity Relationship en_US
dc.title Dihydro-β-agarofuran sesquiterpenes isolated from Celastrus vulcanicola as potential anti-Mycobacterium tuberculosis multidrug-resistant agents en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.bmc.2011.02.034
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.06
dc.relation.issn 1464-3391


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas