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dc.contributor.author | Torres-Romero, D. | |
dc.contributor.author | Jiménez, I.A. | |
dc.contributor.author | Rojas, R. | |
dc.contributor.author | Gilman, Robert Hugh | |
dc.contributor.author | López, M. | |
dc.contributor.author | Bazzocchi, I.L. | |
dc.date.accessioned | 2022-01-18T19:26:45Z | |
dc.date.available | 2022-01-18T19:26:45Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/10842 | |
dc.description.abstract | In the present study, we report four new dihydro-β-agarofuran sesquiterpenes (1-4), which were isolated from the leaves of Celastrus vulcanicola, in addition to five derivatives (5-9). Their stereostructures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques, X-ray studies, chemical correlations and biogenetic means. Compounds 1-9 and the previously reported sesquiterpenes 10-25 have been tested as potential antimycobacterial agents against sensitive and resistant Mycobacterium tuberculosis strains. 1α-Acetoxy-6β,9β-dibenzoyloxy-dihydro- β-agarofuran (20) exhibited antituberculosis activity against the MDR TB strain with a MIC value of 6.2 μg/mL, comparable to or better than isoniazid or rifampin, two of the best first-line drugs commonly used in the treatment of TB. The structure-activity relationship is discussed. | en_US |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofseries | Bioorganic and Medicinal Chemistry | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | article | en_US |
dc.subject | controlled study | en_US |
dc.subject | non|unclassified drug | en_US |
dc.subject | rifampicin | en_US |
dc.subject | Mycobacterium tuberculosis | en_US |
dc.subject | Antitubercular Agents | en_US |
dc.subject | isoniazid | en_US |
dc.subject | multidrug resistant tuberculosis | en_US |
dc.subject | tuberculostatic agent | en_US |
dc.subject | Models, Molecular | en_US |
dc.subject | Drug Resistance, Multiple, Bacterial | en_US |
dc.subject | antibiotic sensitivity | en_US |
dc.subject | minimum inhibitory concentration | en_US |
dc.subject | bacterial strain | en_US |
dc.subject | 1 acetoxy 9 benzoyloxy 8 (dihydroxy 3 phenyl)propanoiloxy 4,6 dihydroxydihydro beta agarofuran | en_US |
dc.subject | 1,4,6,8,9 pentahydroxydihydro beta agarofuran | en_US |
dc.subject | 1,6 diacetoxy 9 benzoyloxy 4,8 dihydroxydihydro beta agarofuran | en_US |
dc.subject | 1,6,8 triacetoxy 4,9 dihydroxydihydro beta agarofuran | en_US |
dc.subject | 1,6,8,9 tetraacetoxy 4 hydroxydihydro beta agarofuran | en_US |
dc.subject | 1,8 diacetoxy 4,6,9 trihydroxydihydro beta agarofuran | en_US |
dc.subject | 1,8 diacetoxy 9 benzoyloxy 6 hydroxydihydro beta agarofuran | en_US |
dc.subject | 1,8 diacetoxy 9 benzoyloxy 6 nicotinoyloxydihydro beta agarofuran | en_US |
dc.subject | 1,8 diacetoxy 9,6 dibenzoyloxy 4 hydroxydihydro beta agarofuran | en_US |
dc.subject | 1alpha acetoxy 6beta,9beta dibenzoyloxydihydro beta agarofuran | en_US |
dc.subject | antimycobacterial agent | en_US |
dc.subject | Celastrus | en_US |
dc.subject | Celastrus vulcanicola | en_US |
dc.subject | Crystallography, X-Ray | en_US |
dc.subject | dihydro beta agarofuran sesquiterpene derivative | en_US |
dc.subject | drug isolation | en_US |
dc.subject | Furans | en_US |
dc.subject | Molecular Structure | en_US |
dc.subject | Multidrug-resistant | en_US |
dc.subject | plant leaf | en_US |
dc.subject | sesquiterpene derivative | en_US |
dc.subject | Sesquiterpenes | en_US |
dc.subject | structure activity relation | en_US |
dc.subject | Structure-Activity Relationship | en_US |
dc.title | Dihydro-β-agarofuran sesquiterpenes isolated from Celastrus vulcanicola as potential anti-Mycobacterium tuberculosis multidrug-resistant agents | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1016/j.bmc.2011.02.034 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.06 | |
dc.relation.issn | 1464-3391 |
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