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New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities

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dc.contributor.author Barea, C.
dc.contributor.author Pabón, A.
dc.contributor.author Castillo Pareja, Denis Helan
dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Quiliano, M.
dc.contributor.author Galiano, S.
dc.contributor.author Pérez-Silanes, S.
dc.contributor.author Monge, A.
dc.contributor.author Deharo, E.
dc.contributor.author Aldana, I.
dc.date.accessioned 2022-01-18T19:26:45Z
dc.date.available 2022-01-18T19:26:45Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10843
dc.description.abstract Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, 14 new 3-amino-1,4-di-N-oxide quinoxaline-2- carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain MHOM/BR/76/LTB-012A. Further computational studies were carried out in order to analyze graphic SAR and ADME properties. The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Bioorganic and Medicinal Chemistry Letters
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animal Cell en_US
dc.subject In Vitro Study en_US
dc.subject Mice en_US
dc.subject Malaria en_US
dc.subject Unclassified Drug en_US
dc.subject Plasmodium Falciparum en_US
dc.subject Antimalarial Agent en_US
dc.subject Chloroquine en_US
dc.subject Leishmaniasis en_US
dc.subject Trypanocidal Agents en_US
dc.subject Intestine Absorption en_US
dc.title New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.bmcl.2011.05.125
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.06
dc.relation.issn 1464-3405


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