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Fertility and estrogenic activity of Turraeanthus africanus in combination with Lepidium meyenii (Black maca) in female mice

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dc.contributor.author Massoma Lembè, D.
dc.contributor.author Gasco Tantachuco, Manuel Enrique
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2022-01-18T19:26:46Z
dc.date.available 2022-01-18T19:26:46Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10851
dc.description.abstract Aim of the study: The effect of Black maca (Lepidium meyenii) and Turraeanthus africanus on fertility and estrogenic activity in female mice was investigated. Materials and methods: Thirty female mice were treated daily with extracts of Black maca plus T. africanus (BM+TA), T. africanus alone (TA) or vehicle (control) at dose 1 g/kg BW for 30 days. Results: The length of the estrous cycle inside the group of (BM+TA)-treated mice significantly (p < 0.001) shorten (4.08 ± 0.06 days) when compared to control (4.53 ± 0.05). On the proestrous stage, the oestradiol level for animals treated with TA (27.3 ± 0.5 pg/ml) and (BM+TA) (36.0 ± 0.9 pg/ml) significantly increased when compared to control (24.0 ± 0.4 pg/ml), while in the estrous stage only the estradiol level of (BM+TA) treated animal (28 ± 2 pg/ml) significantly increased (p < 0.01). The uterine weight of ovariectomized of TA-treated animals was higher (p < 0.05) than those observed in controls while no change in the (BM+TA) group was observed. The weight of uterus of non pregnant mice of both treated TA and (BM+TA) extract significantly increased (p < 0.001) in the proestrous and estrus stage when compared to control. The number of fetuses in the uterus after (BM+TA) treatment (14.66 ± 0.25) was significantly higher (p < 0.05) than the TA treated alone (13.60 ± 0.45) and the control (9.5 ± 1.10) one at day 15 of pregnancy. No significant difference between groups (p > 0.05) was observed for the two treatments concerning the Fertility index. Conclusions: TA can affect the number of embryo implantation and the uterine weight. This effect increased in association with BM. BM could regulate estrous cycle. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries European Journal of Integrative Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Controlled Study en_US
dc.subject Animal Experiment en_US
dc.subject Animal Model|Unclassified Drug en_US
dc.subject Fetus en_US
dc.subject Pregnancy en_US
dc.subject Plant Extract en_US
dc.subject Lepidium en_US
dc.subject Lepidium Meyenii Extract en_US
dc.subject Embryo en_US
dc.subject Embryo Implantation en_US
dc.subject Estradiol en_US
dc.subject Estradiol Level en_US
dc.subject Estrogenocity en_US
dc.subject Estrous Cycle en_US
dc.subject Fertility en_US
dc.subject Meliaceae en_US
dc.subject Nidation en_US
dc.subject Ovariectomy en_US
dc.subject Turraeanthus Africanus Extract en_US
dc.subject Uterus Weight en_US
dc.title Fertility and estrogenic activity of Turraeanthus africanus in combination with Lepidium meyenii (Black maca) in female mice en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.eujim.2012.03.001
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.29
dc.relation.issn 1876-3820


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