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Echinococcus granulosus: Different cytokine profiles are induced by single versus multiple experimental infections in dogs

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dc.contributor.author Rossi, A.
dc.contributor.author Marqués, J.M.
dc.contributor.author Gavidia, C.M.
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author Carmona, C.
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Chabalgoity, J.A.
dc.date.accessioned 2022-01-18T19:26:46Z
dc.date.available 2022-01-18T19:26:46Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10855
dc.description.abstract Modulation of host responses is an important strategy by which parasites ensure successful establishment and persistence. Host counteraction against this modulation may be required for the host to develop resistance to infection. In this pilot study, experimental infection of dogs with Echinococcus granulosus induced a strong polarization of the cytokine response towards a Th2 phenotype. Consecutive rounds of infection and cure induced resistance to infection resulting in a dramatically lower parasite burden. Repeatedly-infected resistant dogs also lost immune polarization and developed a balanced Th1/Th2 response. No major differences were observed in the production of regulatory cytokines (IL-10, TGF-β) between dogs with high parasite load and dogs with only few intestinal parasites. These results suggest that E. granulosus-driven immunomodulation contributes to successful infection in the definitive host. This information might be relevant for the development of more effective vaccines against this stage of the parasite. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Experimental Parasitology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Controlled Study en_US
dc.subject Animal Cell en_US
dc.subject |Nucleotide Sequence en_US
dc.subject Pilot Projects en_US
dc.subject Gamma Interferon en_US
dc.subject Gene Expression en_US
dc.subject Experimental Infection en_US
dc.subject RNA Messenger en_US
dc.subject Cytokines en_US
dc.subject Cytokine Production en_US
dc.subject Echinococcosis en_US
dc.subject Echinococcosis en_US
dc.subject Echinococcus Granulosus en_US
dc.subject Canis Familiaris en_US
dc.subject Dog en_US
dc.subject Infection Resistance en_US
dc.subject Peyer Patch en_US
dc.subject Transforming Growth Factor Beta en_US
dc.title Echinococcus granulosus: Different cytokine profiles are induced by single versus multiple experimental infections in dogs en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.exppara.2011.12.006
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.relation.issn 1090-2449


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