Universidad Peruana Cayetano Heredia

Effects of distance from a heavily transited avenue on asthma and atopy in a periurban shantytown in Lima, Peru

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dc.contributor.author Baumann, L.M.
dc.contributor.author Robinson, C.L.
dc.contributor.author Combe, J.M.
dc.contributor.author Gomez, A.
dc.contributor.author Romero Rivero, Karina Maribel
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Cabrera, L.
dc.contributor.author Hansel, N.N.
dc.contributor.author Wise, R.A.
dc.contributor.author Breysse, P.N.
dc.contributor.author Barnes, K.
dc.contributor.author Hernandez, J.E.
dc.contributor.author Checkley, W.
dc.date.accessioned 2022-01-18T19:26:47Z
dc.date.available 2022-01-18T19:26:47Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10865
dc.description.abstract Background: Proximity to roadways increases the risk of asthma in developed countries; however, relatively little is known about this relationship in developing countries, where rapid and uncontrolled growth of cities has resulted in urban sprawl and heavy traffic volumes. Objective: We sought to determine the effect of distance from a heavily transited avenue on asthma symptoms and quantitative respiratory outcome measures in a periurban shantytown in Lima, Peru. Methods: We enrolled 725 adolescents aged 13 to 15 years who were administered a survey on asthma symptoms and measured spirometry, response to allergy skin testing, and exhaled nitric oxide (eNO). We calculated distances from the main avenue for all households and measured indoor particulate matter in 100 households. We used multivariable regression to model the risk of asthma symptoms, risk of atopy, eNO levels, and FEV1/forced vital capacity ratio as a function of distance. Results: Compared against 384 meters, the odds of current asthma symptoms in households living within 100 meters increased by a factor of 2 (P = .05). The odds of atopy increased by a factor of 1.07 for every 100-meter difference in the distance from the avenue (P = .03). We found an inverse relationship in prebronchodilator FEV1/forced vital capacity and distance to the avenue in female subjects (P = .01) but not in male subjects. We did not find an association between eNO or household particulate matter levels and distance. Conclusion: Living in close proximity to a high-traffic-density avenue in a periurban community in Peru was associated with a greater risk of asthma symptoms and atopy. Regulation of mobile-source pollutants in periurban areas of developing countries might help reduce the burden of asthma symptoms and atopy. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Allergy and Clinical Immunology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject Risk Factors en_US
dc.subject article en_US
dc.subject major clinical study en_US
dc.subject priority journal en_US
dc.subject Demography en_US
dc.subject prevalence en_US
dc.subject Environmental Exposure en_US
dc.subject forced vital capacity en_US
dc.subject household en_US
dc.subject outcome assessment en_US
dc.subject skin test en_US
dc.subject Developing Countries en_US
dc.subject nitric oxide en_US
dc.subject Asthma en_US
dc.subject indoor air pollution en_US
dc.subject particulate matter en_US
dc.subject spirometry en_US
dc.subject corticosteroid en_US
dc.subject Air Pollutants en_US
dc.subject forced expiratory volume en_US
dc.subject Urbanization en_US
dc.subject Asthma symptoms en_US
dc.subject atopy en_US
dc.subject beta adrenergic receptor stimulating agent en_US
dc.subject distance en_US
dc.subject distance perception en_US
dc.subject Hypersensitivity, Immediate en_US
dc.subject traffic en_US
dc.subject Vehicle Emissions en_US
dc.title Effects of distance from a heavily transited avenue on asthma and atopy in a periurban shantytown in Lima, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jaci.2010.11.031
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 1097-6825


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