Universidad Peruana Cayetano Heredia

Mapping of tyrosine hydroxylase in the alpaca (Lama pacos) brainstem and colocalization with CGRP

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dc.contributor.author Marcos, P.
dc.contributor.author Arroyo-Jimenez, M.M.
dc.contributor.author Lozano, G.
dc.contributor.author Aguilar, L.A.
dc.contributor.author Coveñas, R.
dc.date.accessioned 2022-01-18T19:26:47Z
dc.date.available 2022-01-18T19:26:47Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10866
dc.description.abstract The distribution of tyrosine hydroxylase (TH) in the brainstem of alpaca (Lama pacos) has been analysed using immunohistochemical methods. The following catecholaminergic cell nuclei have been detected: A1, C1, A2, C2 and area postrema in the medulla oblongata; A5, A6d, A7sc and A7d in the pons; as have several mesencephalic groups: A8, A9l, A9m, A9v, A9pc, A10, A10c, A10d and A10dc. This nuclear parcellation differs from that found in rodents, but agrees with the results reported in other members of the Artiodactyla order, such as giraffe or pig, and with the catecholaminergic distribution detected in species of other mammalian orders. Thus, these findings support the hypothesis that the animals included in the same order show the same nuclear complement in the neuromodulatory systems. In addition, it seems that other species share the same catecholaminergic groups as the alpaca, suggesting that a specific nuclear disposition was important and worth maintaining throughout evolution. Moreover, the distribution of TH has been compared with that of CGRP by double immunohistochemistry. Double-labelled neurons were very isolated and observed only in a few catecholaminergic groups: A1 and C2 in the medulla oblongata, A6d, A7sc and A7d in the pons, and A9l in the mesencephalon. However, interaction between TH and CGRP may be possible in more brainstem regions, particularly the area postrema. This interaction may prove important in the regulation of the specific cardiovascular control of alpacas given their morphological characteristics. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Chemical Neuroanatomy
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject animal tissue en_US
dc.subject Animals en_US
dc.subject calcitonin gene related peptide en_US
dc.subject Calcitonin Gene-Related Peptide en_US
dc.subject non|priority journal en_US
dc.subject immunohistochemistry en_US
dc.subject Immunohistochemistry en_US
dc.subject Artiodactyla en_US
dc.subject Species Specificity en_US
dc.subject Phylogeny en_US
dc.subject protein localization en_US
dc.subject gene mapping en_US
dc.subject Camelids, New World en_US
dc.subject Neurons en_US
dc.subject Catecholaminergic cell groups en_US
dc.subject tyrosine 3 monooxygenase en_US
dc.subject Tyrosine 3-Monooxygenase en_US
dc.subject Area Postrema en_US
dc.subject Brain Mapping en_US
dc.subject brain region en_US
dc.subject brain stem en_US
dc.subject Catecholamines en_US
dc.subject Cell Nucleus en_US
dc.subject CGRP en_US
dc.subject experimental pig en_US
dc.subject Medulla oblongata en_US
dc.subject Mesencephalon en_US
dc.subject neuromodulation en_US
dc.subject Pons en_US
dc.title Mapping of tyrosine hydroxylase in the alpaca (Lama pacos) brainstem and colocalization with CGRP en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jchemneu.2010.10.002
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.04
dc.relation.issn 1873-6300


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