Universidad Peruana Cayetano Heredia

Antileishmanial sesquiterpene lactones from Pseudelephantopus spicatus, a traditional remedy from the Chayahuita Amerindians (Peru). Part III

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dc.contributor.author Odonne, G.
dc.contributor.author Herbette, G.
dc.contributor.author Eparvier, V.
dc.contributor.author Bourdy, G.
dc.contributor.author Rojas, R.
dc.contributor.author Sauvain, Michel Henri Auguste
dc.contributor.author Stien, D.
dc.date.accessioned 2022-01-18T19:26:47Z
dc.date.available 2022-01-18T19:26:47Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10870
dc.description.abstract Ethnopharmacological relevance: The study of traditional remedies used by the Chayahuita, an ethnic group from the Peruvian Amazonia, has prompted us to investigate in detail the ethanolic extract of Pseudelephantopus spicatus (Juss. ex Aubl.) C.F. Baker, which has demonstrated strong biological activity towards Leishmania amazonensis. Our goal was to discover the active compound of this plant-based remedy. Materials and methods: A bioguided fractionation of the crude extract was undertaken based on the biological activity recorded against Leishmania amazonensis axenic amastigotes in in vitro bioassays. Results: Three strongly to moderately active compounds were isolated: two hirsutinolides (the 8,13-diacetyl-piptocarphol and the 8-acetyl-13-O-ethyl-piptocarphol) and ursolic acid. IC50 against Leishmania amazonensis axenic amastigotes are respectively 0.2, 0.37 and 0.99 μM (while IC50 of amphotericin B is 0.41 μM). These compounds have never been isolated from this plant species, and germacranolides have never been identified as potential antileishmanial agents. Conclusions: The compounds isolated from Pseudelephantopus spicatus account for the antileishmanial activity of the plant, thus giving support to its use by the Chayahuita in Peru. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Ethnopharmacology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject In Vitro Study|Unclassified Drug en_US
dc.subject Leishmaniasis en_US
dc.subject Trypanocidal Agents en_US
dc.subject Indians South American en_US
dc.subject Amastigote en_US
dc.subject Leishmaniasis en_US
dc.subject Dose-Response Relationship Drug en_US
dc.subject Plant Extracts en_US
dc.subject Medicinal Plant en_US
dc.subject Amphotericin B en_US
dc.subject Sesquiterpenes en_US
dc.subject IC 50 en_US
dc.subject Leishmania Amazonensis en_US
dc.subject Antileishmanial Agent en_US
dc.subject Inhibitory Concentration 50 en_US
dc.subject Medicine Traditional en_US
dc.subject Chayahuita en_US
dc.subject 813 Diacetylpiptocarphol en_US
dc.subject Acetyl 13 O Ethylpiptocarphol en_US
dc.subject Asteraceae en_US
dc.subject Biological Activity en_US
dc.subject Chemical Fractionation en_US
dc.subject Hirsutinolides en_US
dc.subject Lactones en_US
dc.subject Plant Components Aerial en_US
dc.subject Pseudelephantopus Spicatus Extract en_US
dc.subject Sesquiterpene Lactone Derivative en_US
dc.subject Traditional Remedy en_US
dc.subject Triterpenes en_US
dc.subject Ursolic Acid en_US
dc.title Antileishmanial sesquiterpene lactones from Pseudelephantopus spicatus, a traditional remedy from the Chayahuita Amerindians (Peru). Part III en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jep.2011.07.008
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1872-7573


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