Universidad Peruana Cayetano Heredia

Antimicrobial resistance and molecular typing of Staphylococcus aureus bloodstream isolates from hospitals in Peru

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dc.contributor.author García Apac, Coralith Marlinda
dc.contributor.author Rijnders, M.I.A.
dc.contributor.author Bruggeman, C.
dc.contributor.author Samalvides Cuba, Frine
dc.contributor.author Stobberingh, E.E.
dc.contributor.author Jacobs, J.
dc.date.accessioned 2022-01-18T19:26:47Z
dc.date.available 2022-01-18T19:26:47Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10876
dc.description.abstract Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) infections are of worldwide concern. The present study describes the antimicrobial resistance and molecular typing of methicillin-resistant and methicillin-susceptible S. aureus (MSSA) bloodstream isolates in Peru. Methods: Consecutive non-duplicate S. aureus bloodstream isolates were collected over a 15-month period (2008-2009) from seven hospitals in Lima and Callao, two contiguous cities in Peru. Detection of mecA gene, spa typing and Staphylococcal Chromosomal Cassette (SCC). mec typing were performed. Antimicrobial resistance was assessed by disk diffusion. Results: Of 338 isolates, MRSA rate was 50.0%. Among MRSA isolates (n = 169), 81.7% were associated to MLST CC5, 68.8% had spa t149/SCC. mec I, and more than 85% were co-resistant to ciprofloxacin, clindamycin, erythromycin and gentamicin; 8.9% (n = 15) were associated to MLST CC8, 14 of them had spa t148/SCC. mec IV, and more than 70% were co-resistant to ciprofloxacin, clindamycin and erythromycin. Among MSSA isolates (n = 169), there was a higher diversity of spa types (n = 56) compared to MRSA isolates (n = 17), 27.2% were associated to MLST CC8, 23.7% were resistant to erythromycin and clindamycin resistance exceeded 20%. Conclusions: MRSA rate among bloodstream isolates in Peru was 50%, with MLST CC5/t149/SCC. mec I representing the most frequent clone. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Infection
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru|Latin America en_US
dc.subject Rifampicin en_US
dc.subject Infant Newborn en_US
dc.subject Newborn en_US
dc.subject Bacterium Detection en_US
dc.subject Anti-Bacterial Agents en_US
dc.subject Bacteremia en_US
dc.subject Bacterial Gene en_US
dc.subject Blood Culture en_US
dc.subject Bacterium Isolate en_US
dc.subject Molecular Typing en_US
dc.subject Microbial Sensitivity Tests en_US
dc.subject Ciprofloxacin en_US
dc.subject Gentamicin en_US
dc.subject Chloramphenicol en_US
dc.subject Antibiotic Resistance en_US
dc.subject Clindamycin en_US
dc.subject Drug Resistance Bacterial en_US
dc.subject Blood Analysis en_US
dc.subject Erythromycin en_US
dc.subject Methicillin Resistant Staphylococcus Aureus en_US
dc.subject Genes Bacterial en_US
dc.subject Disk Diffusion en_US
dc.subject Staphylococcal Infections en_US
dc.subject Staphylococcus Aureus en_US
dc.subject Bacterial Transmission en_US
dc.subject Molecular Typing en_US
dc.subject Gene Identification en_US
dc.subject Hospitals en_US
dc.subject Meca Gene en_US
dc.subject Molecular Characteristics en_US
dc.subject Sccmec I Gene en_US
dc.subject Sccmec IV Gene en_US
dc.subject Staphylococcal Protein A en_US
dc.title Antimicrobial resistance and molecular typing of Staphylococcus aureus bloodstream isolates from hospitals in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jinf.2012.06.009
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1532-2742


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