Universidad Peruana Cayetano Heredia

Multilocus genotyping reveals a polyphyletic pattern among naturally antimony-resistant Leishmania braziliensis isolates from Peru

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dc.contributor.author Adaui, V.
dc.contributor.author Maes, I.
dc.contributor.author Huyse, T.
dc.contributor.author Van den Broeck, F.
dc.contributor.author Talledo Albujar, Michael John
dc.contributor.author Kuhls, K.
dc.contributor.author De Doncker, S.
dc.contributor.author Maes, L.
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Schönian, G.
dc.contributor.author Arévalo Zelada, Jorge Luis
dc.contributor.author Dujardin, J.-C.
dc.date.accessioned 2022-01-18T19:26:47Z
dc.date.available 2022-01-18T19:26:47Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10879
dc.description.abstract In order to understand the epidemiological dynamics of antimonial (Sb V) resistance in zoonotic tegumentary leishmaniasis and its link with treatment outcome, we analyzed the population structure of 24 Peruvian Leishmania braziliensis clinical isolates with known in vitro antimony susceptibility and clinical phenotype by multilocus microsatellite typing (14 microsatellite loci). The genetic variability in the Peruvian isolates was high and the multilocus genotypes were strongly differentiated from each other. No correlation was found between the genotypes and in vitro drug susceptibility or clinical treatment outcome. The finding of a polyphyletic pattern among the Sb V-resistant L. braziliensis might be explained by (i) independent events of drug resistance emergence, (ii) sexual recombination and/or (iii) other phenomena mimicking recombination signals. Interestingly, the polyphyletic pattern observed here is very similar to the one we observed in the anthroponotic Leishmania donovani (Laurent et al., 2007), hereby questioning the role of transmission and/or chemotherapeutic drug pressure in the observed population structure. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Infection, Genetics and Evolution
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject In Vitro Study en_US
dc.subject Genotype en_US
dc.subject Microsatellite Marker en_US
dc.subject Parasite Transmission en_US
dc.subject Drug Resistance en_US
dc.subject Genetic Variation en_US
dc.subject Sexual Behavior en_US
dc.subject Leishmania Braziliensis en_US
dc.subject Leishmaniasis Cutaneous en_US
dc.subject Skin Leishmaniasis en_US
dc.subject Treatment Outcome en_US
dc.subject Microsatellite Repeats en_US
dc.subject Population Structure en_US
dc.subject Gene Locus en_US
dc.subject Genetic Variability en_US
dc.subject Molecular Epidemiology en_US
dc.subject Antiprotozoal Agents en_US
dc.subject Parasitic Sensitivity Tests en_US
dc.subject Molecular Dynamics en_US
dc.subject Genetic Recombination en_US
dc.subject Zoonosis en_US
dc.subject Parasite Isolation en_US
dc.subject Drug Sensitivity en_US
dc.subject Antimony en_US
dc.subject Leishmania Donovani en_US
dc.subject Antimony Resistance en_US
dc.subject Clinical Isolates en_US
dc.subject Microsatellite Markers en_US
dc.subject Polyphyly en_US
dc.subject Population Genetics en_US
dc.subject Structure Analysis en_US
dc.subject Zoonotic Tegumentary Leishmaniasis en_US
dc.title Multilocus genotyping reveals a polyphyletic pattern among naturally antimony-resistant Leishmania braziliensis isolates from Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.meegid.2011.08.008
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1567-7257


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