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Evolution of the Leishmania braziliensis species complex from amplified fragment length polymorphisms, and clinical implications

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dc.contributor.author Odiwuor, S.
dc.contributor.author Veland, N.
dc.contributor.author Maes, I.
dc.contributor.author Arévalo Zelada, Jorge Luis
dc.contributor.author Dujardin, J.-C.
dc.contributor.author Van der Auwera, G.
dc.date.accessioned 2022-01-18T19:26:47Z
dc.date.available 2022-01-18T19:26:47Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10882
dc.description.abstract In order to get more insight into its evolution and geographical distribution, we investigated the Leishmania (Viannia) braziliensis species complex using amplified fragment length polymorphisms and sequencing of a heat-shock protein 70 gene fragment. Previously, several assays had alluded to the high genetic diversity of the group, and single-locus assays typically identified two species, i.e. L. braziliensis and Leishmania peruviana, with occasional genetic signatures of both in the same strain. By analysis of 53 parasite isolates from Peru, and eight additional ones from other countries, we identified an atypical L. braziliensis cluster, and confirmed the origin of L. peruviana from the L. braziliensis cluster during the colonization of the western Andean coastal valleys. We discuss the clinical and taxonomical implications of our findings in relation to currently used species typing assays. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Infection, Genetics and Evolution
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject article en_US
dc.subject controlled study en_US
dc.subject non|priority journal en_US
dc.subject Genotype en_US
dc.subject nucleotide sequence en_US
dc.subject Leishmania braziliensis en_US
dc.subject Leishmaniasis, Cutaneous en_US
dc.subject Reproducibility of Results en_US
dc.subject Cluster Analysis en_US
dc.subject gene frequency en_US
dc.subject population structure en_US
dc.subject Bolivia en_US
dc.subject Leishmania en_US
dc.subject gene locus en_US
dc.subject DNA extraction en_US
dc.subject genetic variability en_US
dc.subject heat shock protein 70 en_US
dc.subject Leishmania peruviana en_US
dc.subject Phylogeny en_US
dc.subject sequence analysis en_US
dc.subject parasite isolation en_US
dc.subject HSP70 Heat-Shock Proteins en_US
dc.subject taxonomy en_US
dc.subject AFLP en_US
dc.subject amplified fragment length polymorphism en_US
dc.subject Amplified Fragment Length Polymorphism Analysis en_US
dc.subject genetic conservation en_US
dc.subject Heat-shock protein 70 en_US
dc.subject Leishmania braziliensis species complex en_US
dc.subject Tegumentary leishmaniasis en_US
dc.title Evolution of the Leishmania braziliensis species complex from amplified fragment length polymorphisms, and clinical implications en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.meegid.2012.03.028
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1567-7257

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