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Activity-guided isolation of antileishmanial compounds from Piper hispidum

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dc.contributor.author Ruiz, C.
dc.contributor.author Haddad, M.
dc.contributor.author Alban, J.
dc.contributor.author Bourdy, G.
dc.contributor.author Reategui, R.
dc.contributor.author Castillo Pareja, Denis Helan
dc.contributor.author Sauvain, Michel Henri Auguste
dc.contributor.author Deharo, E.
dc.contributor.author Estevez, Y.
dc.contributor.author Arévalo Zelada, Jorge Luis
dc.contributor.author Rojas, R.
dc.date.accessioned 2022-01-18T19:26:48Z
dc.date.available 2022-01-18T19:26:48Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10885
dc.description.abstract The bioassay-guided purification of the ethanolic extract from the leaves of Piper hispidum led to the isolation of one new amide, N-2-(3′,4′, 5′-trimethoxyphenyl)ethyl-2-hydroxybenzamide (1) as well as two known chalcones 2′-hydroxy-3′,4′,6′-trimethoxychalcone (2); 2′,4′-dihydroxy-6′-methoxychalcone (cardamonin, 3) and one known flavanone, 5,7-dihydroxyflavanone (Pinocembrin, 4). Their structures were elucidated on the basis of spectroscopic data, including homo- and heteronuclear correlation NMR experiments (COSY, HSQC and HMBC) and comparison with data reported in the literature. The isolated compounds were tested against Leishmania amazonensis axenic amastigotes. The results showed that the known chalcone 2 exhibited the most potent antileishmanial activity with an IC 50 of 0.8 μM (amphotericin B: IC50 = 0.2 μM) but was shown to exhibit mild cytotoxicity. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Phytochemistry Letters
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject male en_US
dc.subject article en_US
dc.subject comparative study en_US
dc.subject controlled study en_US
dc.subject animal cell en_US
dc.subject in vitro study en_US
dc.subject non|priority journal en_US
dc.subject unclassified drug en_US
dc.subject Leishmaniasis en_US
dc.subject Leishmania en_US
dc.subject plant extract en_US
dc.subject amphotericin B en_US
dc.subject nuclear magnetic resonance en_US
dc.subject drug isolation en_US
dc.subject plant leaf en_US
dc.subject cytotoxicity en_US
dc.subject drug structure en_US
dc.subject antiprotozoal activity en_US
dc.subject IC 50 en_US
dc.subject Leishmania amazonensis en_US
dc.subject antileishmanial agent en_US
dc.subject Chalcone en_US
dc.subject chalcone derivative en_US
dc.subject peritoneum macrophage en_US
dc.subject fractionation en_US
dc.subject Piperaceae en_US
dc.subject Piper en_US
dc.subject 2' hydroxy 3',4',6' trimethoxychalcone en_US
dc.subject 2',4' dihydroxy 6' methoxychalcone en_US
dc.subject amide en_US
dc.subject Amide en_US
dc.subject Flavanone en_US
dc.subject n 2 (3',4',5' trimethoxyphenyl)ethyl 2 hydroxybenzamide en_US
dc.subject pinocembrine en_US
dc.subject Piper hispidum en_US
dc.title Activity-guided isolation of antileishmanial compounds from Piper hispidum en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.phytol.2011.08.001
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1874-3900


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