Universidad Peruana Cayetano Heredia

Randomized trial of HPV4 vaccine assessing the response to HPV4 vaccine in two schedules among Peruvian female sex workers

Mostrar el registro sencillo del ítem

dc.contributor.author Brown, B.
dc.contributor.author Blas Blas, Magaly Marlitz
dc.contributor.author Cabral, A.
dc.contributor.author Cárcamo Cavagnaro, César Paul Eugenio
dc.contributor.author Gravitt, P.
dc.contributor.author Halsey, N.
dc.date.accessioned 2022-01-18T19:26:48Z
dc.date.available 2022-01-18T19:26:48Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10894
dc.description.abstract Two hundred female sex workers (FSWs) in Lima, Peru were randomized to receive HPV4 vaccine in the standard (0, 2, 6 months) or a modified schedule (0, 3, 6 months). One hundred and eighty four (92%) participants completed 3 doses of vaccine. Baseline seropositive rates were 58% for HPV6, 22.5% for HPV11, 41.5% for HPV16, and 13% for HPV18. The final geometric mean antibody titer (GMT) following vaccination was significantly greater for women who were seropositive at baseline compared to seronegative women: HPV6 (GMT ratio = 2.3, p< 0.01), HPV11 (GMT ratio = 2.7, p< 0.01), HPV16 (GMT ratio = 1.3, p= 0.04), and HPV18 (GMT ratio = 2.4, p< 0.01). Antibody titers in the modified schedule were not inferior to those in the standard schedule, suggesting the modified schedule may be paired with required STD visits. Although all women benefit from vaccination, administration at a younger age and before sexual debut is needed to achieve maximum protection from vaccine. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Vaccine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject article en_US
dc.subject controlled study en_US
dc.subject major clinical study en_US
dc.subject priority journal en_US
dc.subject sexual behavior en_US
dc.subject prostitution en_US
dc.subject Sex Workers en_US
dc.subject Treatment Outcome en_US
dc.subject randomized controlled trial en_US
dc.subject antibody response en_US
dc.subject antibody titer en_US
dc.subject Vaccination en_US
dc.subject groups by age en_US
dc.subject absence of side effects en_US
dc.subject drug response en_US
dc.subject condyloma acuminatum en_US
dc.subject Human papillomavirus type 11 en_US
dc.subject Human papillomavirus type 16 en_US
dc.subject Human papillomavirus type 18 en_US
dc.subject Human papillomavirus type 6 en_US
dc.subject Papillomavirus Infections en_US
dc.subject Papillomavirus Vaccines en_US
dc.subject Wart virus vaccine en_US
dc.subject uterine cervix cancer en_US
dc.subject drug withdrawal en_US
dc.subject Immune response en_US
dc.subject Antibodies, Viral en_US
dc.subject HPV vaccine en_US
dc.subject Female sex workers en_US
dc.subject Human papillomavirus en_US
dc.subject virus DNA en_US
dc.subject Alphapapillomavirus en_US
dc.subject Adherence en_US
dc.subject virus antibody en_US
dc.subject cancer immunization en_US
dc.subject Cervix Uteri en_US
dc.subject Gammapapillomavirus en_US
dc.subject Immunization Schedule en_US
dc.subject virus immunity en_US
dc.title Randomized trial of HPV4 vaccine assessing the response to HPV4 vaccine in two schedules among Peruvian female sex workers en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.vaccine.2012.01.058
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1873-2518


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas