Universidad Peruana Cayetano Heredia

The highly antigenic 53/25kDa Taenia solium protein fraction with cathepsin-L like activity is present in the oncosphere/cysticercus and induces non-protective IgG antibodies in pigs

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dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Pajuelo Travezaño, Monica Jhenny
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Gutiérrez, A.H.
dc.contributor.author Rueda, L.D.
dc.contributor.author Flores, M.
dc.contributor.author Chile Andrade, Nancy
dc.contributor.author Verastegui Pimentel, Manuela Renee
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Sheen Cortavarria, Patricia
dc.date.accessioned 2022-01-18T19:26:48Z
dc.date.available 2022-01-18T19:26:48Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10895
dc.description.abstract Cathepsin L-like proteases are secreted by several parasites including Taenia solium. The mechanism used by T. solium oncospheres to degrade and penetrate the intestine and infect the host is incompletely understood. It is assumed that intestinal degradation is driven by the proteolytic activity of enzymes secreted by the oncosphere. Blocking the proteolytic activity by an antibody response would prevent the oncosphere penetration and further infection. Serine and cysteine proteases including chymotrypsin, trypsin, elastase, and cathepsin L, are secreted by T. solium and Taenia saginata oncospheres when cultured in vitro, being potential vaccine candidates. However, the purification of a sufficient quantity of proteases secreted by oncospheres to conduct a vaccine trial is costly and lengthy. A 53/25 kDa cathepsin L-like fraction partially purified from T. solium cyst fluid was described previously as an important antigen for immunodiagnostics. In this study we found that this antigen is present in the T. solium oncosphere and is also secreted by the cysticercus. This protein fraction was tested for its ability to protect pigs against an oral challenge with T. solium oncospheres in a vaccine trial. IgG antibodies against the 53/25 kDa cathepsin L-like protein fraction were elicited in the vaccinated animals but did not confer protection. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Veterinary Immunology and Immunopathology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Controlled Study en_US
dc.subject Animal Experiment en_US
dc.subject Animal Model en_US
dc.subject In Vitro Study|Unclassified Drug en_US
dc.subject Drug Efficacy en_US
dc.subject Placebo en_US
dc.subject Immunoglobulin G en_US
dc.subject Infection Control en_US
dc.subject Antibody Response en_US
dc.subject Antigenicity en_US
dc.subject Immunity en_US
dc.subject Immunization en_US
dc.subject Vaccination en_US
dc.subject Taenia Solium en_US
dc.subject Cysticercosis en_US
dc.subject Swine Diseases en_US
dc.subject Enzyme Activity en_US
dc.subject Antigens Helminth en_US
dc.subject Serodiagnosis en_US
dc.subject Cathepsin L en_US
dc.subject Cysticercus en_US
dc.subject Vaccine en_US
dc.subject Hydrolysis en_US
dc.subject Protein Degradation en_US
dc.subject Protein Analysis en_US
dc.subject Taenia Saginata en_US
dc.subject Suidae en_US
dc.subject Vaccine en_US
dc.subject Helminth Proteins en_US
dc.subject Adjuvant Therapy en_US
dc.subject Oncosphere en_US
dc.subject Protease en_US
dc.subject Saponin en_US
dc.subject Intestine Epithelium en_US
dc.subject Molecular Weight en_US
dc.subject Taenia Solium Protein Cathepsin L Fraction en_US
dc.title The highly antigenic 53/25kDa Taenia solium protein fraction with cathepsin-L like activity is present in the oncosphere/cysticercus and induces non-protective IgG antibodies in pigs en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.vetimm.2011.11.002
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#4.03.01
dc.relation.issn 0165-2427


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