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Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum

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dc.contributor.author Aponte, J.C.
dc.contributor.author Jin, Z.
dc.contributor.author Vaisberg Wollach, Abraham Jaime
dc.contributor.author Castillo Pareja, Denis Helan
dc.contributor.author Málaga, E.
dc.contributor.author Lewis, W.H.
dc.contributor.author Sauvain, Michel Henri Auguste
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Hammond, G.B.
dc.date.accessioned 2022-01-18T19:26:49Z
dc.date.available 2022-01-18T19:26:49Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10921
dc.description.abstract An anticancer-bioassay guided isolation of the ethanol extract and fractions of two plants from the Peruvian rainforest, Mikania decora and Cremastosperma microcarpum, led to the characterization of one abundant diterpene, ent-pimara-8(14),15-dien-19-oic acid (1), three thymol derivatives, 10-acetoxy-8,9-dehydro-6-methoxythymol butyrate (2), 10-acetoxy-8,9-epoxy-6- methoxythymol isobutyrate (3), and acetylschizoginol (4), as well as one neolignan, (±)-trans-dehydrodiisoeugenol (5). Only the latter was isolated from C. microcarpum. These compounds exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 3 and 4 were also investigated for their in vitro antileishmanial and trypanocidal activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes. en_US
dc.language.iso eng
dc.publisher Georg Thieme Verlag
dc.relation.ispartofseries Planta Medica
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject Controlled Study en_US
dc.subject Animal Cell en_US
dc.subject Human Cell en_US
dc.subject Trypanosoma Cruzi en_US
dc.subject Antiinfective Agent en_US
dc.subject Leishmania en_US
dc.subject Plant Extract en_US
dc.subject Melanoma en_US
dc.subject Antimicrobial Activity en_US
dc.subject Drug Isolation en_US
dc.subject Cancer Cell Culture en_US
dc.subject Cell Line Tumor en_US
dc.subject Embryo en_US
dc.subject Antineoplastic Activity en_US
dc.subject Drug Cytotoxicity en_US
dc.subject Drug Mechanism en_US
dc.subject IC 50 en_US
dc.subject Lung Cancer en_US
dc.subject Plant Leaves en_US
dc.subject 10 Acetoxy 89 Dehydro 6 Methoxythymol Butyrate en_US
dc.subject 10 Acetoxy 89 Epoxy 6 Methoxythymol Isobutyrate en_US
dc.subject Acetylschizoginol en_US
dc.subject Annonaceae en_US
dc.subject Anticancer en_US
dc.subject Antileishmania en_US
dc.subject Breast Adenocarcinoma en_US
dc.subject Colon Adenocarcinoma en_US
dc.subject Compositae en_US
dc.subject Cremastosperma Microcarpum Annonaceae en_US
dc.subject Diterpenes en_US
dc.subject Mikania Decora en_US
dc.subject Myeloid Leukemia en_US
dc.subject Prostate Carcinoma en_US
dc.subject Thymol en_US
dc.subject Trees en_US
dc.subject Trypanoside en_US
dc.title Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1055/s-0030-1270960
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1439-0221


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