Universidad Peruana Cayetano Heredia

Dihydrochalcones and benzoic acid derivatives from piper dennisii

Dihydrochalcones and benzoic acid derivatives from piper dennisii

Cabanillas Amado, Billy Joel; Le Lamer, A.-C.; Castillo Pareja, Denis Helan; Arévalo Zelada, Jorge Luis; Estevez, Y.; Rojas, R.; Valadeau, C.; Bourdy, G.; Sauvain, Michel Henri Auguste; Fabre, N.
URI: https://hdl.handle.net/20.500.12866/10922
Fecha: 2012

Resumen:

Two new dihydrochalcones, as well as eight known compounds, piperaduncin C, 2,6-dihydroxy-4-methoxydihydrochalcone, 4,2,6-trihydroxy-4-methoxydihydrochalcone, 4-hydroxy-3,5-bis(3-methyl-2- butenyl)-benzoic acid, 3,5-bis(3-methyl-2-butenyl)-4-methoxybenzoic acid, 4-hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)-benzoic acid, 2,2-dimethyl-8-(3-methyl-2-butenyl)-2H-1-chromene-6-carboxylic acid, and 3-(3,7-dimethyl-2,6-octadienyl)-4-methoxybenzoic acid were isolated from the leaves of Piper dennisii Trelease (Piperaceae), using a bioassay-guided fractionation to determine their antileishmanial potential. Among them, compound 10 exhibited the best antileishmanial activity (IC= 20.8 M) against axenic amastigote forms of Leishmania amazonensis, with low cytotoxicity on murine macrophages. In the intracellular macrophage-infected model, compound 10 proved to be more active (IC= 4.2 M). The chemical structures of compounds 1-10 were established based on the analysis of the spectroscopic data.

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