Universidad Peruana Cayetano Heredia

Multiple independent introductions of Plasmodium falciparum in South America

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dc.contributor.author Yalcindag, E.
dc.contributor.author Elguero, E.
dc.contributor.author Arnathau, C.
dc.contributor.author Durand, P.
dc.contributor.author Akiana, J.
dc.contributor.author Anderson, T.J.
dc.contributor.author Aubouy, A.
dc.contributor.author Balloux, F.
dc.contributor.author Besnard, P.
dc.contributor.author Bogreau, H.
dc.contributor.author Carnevale, P.
dc.contributor.author D'Alessandro, U.
dc.contributor.author Fontenille, D.
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Jombart, T.
dc.contributor.author Le Mire, J.
dc.contributor.author Leroy, E.
dc.contributor.author Maestre, A.
dc.contributor.author Mayxay, M.
dc.contributor.author Ménard, D.
dc.contributor.author Musset, L.
dc.contributor.author Newton, P.N.
dc.contributor.author Nkoghé, D.
dc.contributor.author Noya, O.
dc.contributor.author Ollomo, B.
dc.contributor.author Rogier, C.
dc.contributor.author Veron, V.
dc.contributor.author Wide, A.
dc.contributor.author Zakeri, S.
dc.contributor.author Carme, B.
dc.contributor.author Legrand, E.
dc.contributor.author Chevillon, C.
dc.contributor.author Ayala, F.J.
dc.contributor.author Renaud, F.
dc.contributor.author Prugnolle, F.
dc.date.accessioned 2022-01-18T19:26:50Z
dc.date.available 2022-01-18T19:26:50Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10926
dc.description.abstract The origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence - archeological and genetic - suggests a much older origin. We collected and analyzed P. falciparum isolates from different regions of the world, encompassing the distribution range of the parasite, including populations from sub-Saharan Africa, the Middle East, Southeast Asia, and South America. Analyses of microsatellite and SNP polymorphisms show that the populations of P. falciparum in South America are subdivided in two main genetic clusters (northern and southern). Phylogenetic analyses, as well as Approximate Bayesian Computation methods suggest independent introductions of the two clusters from African sources. Our estimates of divergence time between the South American populations and their likely sources favor a likely introduction from Africa during the transatlantic slave trade. en_US
dc.language.iso eng
dc.publisher National Academy of Sciences
dc.relation.ispartofseries Proceedings of the National Academy of Sciences of the United States of America
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Logistic Models|Phylogeny en_US
dc.subject Geographic Distribution en_US
dc.subject Demography en_US
dc.subject Plasmodium Falciparum en_US
dc.subject South America en_US
dc.subject Genetic Variation en_US
dc.subject Polymorphism Single Nucleotide en_US
dc.subject |Genetics Population en_US
dc.subject Cluster Analysis en_US
dc.subject Microsatellite Repeats en_US
dc.subject Models Genetic en_US
dc.subject Bayes Theorem en_US
dc.subject Phylogeography en_US
dc.subject Emigration And Immigration en_US
dc.subject Africa en_US
dc.subject Genetic Diversity|East en_US
dc.subject Microsatellite DNA en_US
dc.subject Principal Component Analysis en_US
dc.subject Genetic Distance en_US
dc.subject Human Migrations en_US
dc.subject Malaria Origin en_US
dc.subject New World en_US
dc.subject Southeast Asia en_US
dc.title Multiple independent introductions of Plasmodium falciparum in South America en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1073/pnas.1119058109
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1091-6490


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