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Bronchiectasis is associated with human T-lymphotropic virus 1 infection in an Indigenous Australian population

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dc.contributor.author Einsiedel, L.
dc.contributor.author Fernandes, L.
dc.contributor.author Spelman, T.
dc.contributor.author Steinfort, D.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2022-01-18T19:26:51Z
dc.date.available 2022-01-18T19:26:51Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10946
dc.description.abstract Background. Recent studies suggest that infection with human T-lymphotropic virus 1 (HTLV-1) might be associated with bronchiectasis among Indigenous Australians. The present study compared the clinical characteristics and outcomes of bronchiectasis in this population, according to HTLV-1 serologic status. Methods. We performed a retrospective cohort study of Indigenous adults with bronchiectasis and known HTLV-1 serologic status admitted to Alice Springs Hospital, central Australia, from January 2000 through December 2006. Results. Among 89 Indigenous adults whose HTLV-1 serologic status was confirmed, 52 (58.4%) were HTLV-1 seropositive. Differences between HTLV-1-seropositive and HTLV-1-seronegative groups were apparent in childhood presentations and adult outcomes. Among adults, an increasing number of bronchiectatic lobes (univariable odds ratio [OR], 1.51; 95% confidence interval [CI]; 1.03-2.20; P =. 033) and the presence of ground-glass opacities at chest high-resolution computed tomography (univariable OR, 8.54; 95% CI, 1.04-70.03; P =. 046) predicted HTLV-1 infection. Cor pumonale (HTLV-1-positive group, 10/52; HTLV-1-negative group, 1/37; P =. 023) was more frequent among HTLV-1-seropositive adults, who also experienced a higher disease-specific mortality (univariable OR, 5.78; 95% CI, 1.17-26.75; P =. 028). Only HTLV-1-seropositive patients were admitted specifically for the treatment of infected skin lesions, and this finding predicted death (multivariable OR, 6.77; 95% CI, 1.46-31.34; P =. 014). Overall mortality was high; 34.2% of the cohort died at a median age of 42.5 years. Conclusions. HTLV-1 infection contributes to the risk of developing bronchiectasis and worsens outcomes among Indigenous Australians. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Clinical Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Cohort Studies en_US
dc.subject Controlled Study en_US
dc.subject Population Research en_US
dc.subject Disease Association en_US
dc.subject Infant en_US
dc.subject Retrospective Studies en_US
dc.subject School |Mortality en_US
dc.subject HTLV-I Infections en_US
dc.subject Human T Cell Leukemia Virus 1 en_US
dc.subject Human T-Lymphotropic Virus 1 en_US
dc.subject Treatment Outcome en_US
dc.subject Survival Analysis en_US
dc.subject Outcome Assessment en_US
dc.subject Computer Assisted Tomography en_US
dc.subject Skin Defect en_US
dc.subject Population Groups en_US
dc.subject Australia en_US
dc.subject Bronchiectasis en_US
dc.subject Cor Pulmonale en_US
dc.subject Human T Cell Leukemia Virus 1 Infection en_US
dc.subject Retrovirus Infection en_US
dc.title Bronchiectasis is associated with human T-lymphotropic virus 1 infection in an Indigenous Australian population en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/cid/cir766
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6591


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