dc.contributor.author | Einsiedel, L. | |
dc.contributor.author | Fernandes, L. | |
dc.contributor.author | Spelman, T. | |
dc.contributor.author | Steinfort, D. | |
dc.contributor.author | Gotuzzo Herencia, José Eduardo | |
dc.date.accessioned | 2022-01-18T19:26:51Z | |
dc.date.available | 2022-01-18T19:26:51Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/10946 | |
dc.description.abstract | Background. Recent studies suggest that infection with human T-lymphotropic virus 1 (HTLV-1) might be associated with bronchiectasis among Indigenous Australians. The present study compared the clinical characteristics and outcomes of bronchiectasis in this population, according to HTLV-1 serologic status. Methods. We performed a retrospective cohort study of Indigenous adults with bronchiectasis and known HTLV-1 serologic status admitted to Alice Springs Hospital, central Australia, from January 2000 through December 2006. Results. Among 89 Indigenous adults whose HTLV-1 serologic status was confirmed, 52 (58.4%) were HTLV-1 seropositive. Differences between HTLV-1-seropositive and HTLV-1-seronegative groups were apparent in childhood presentations and adult outcomes. Among adults, an increasing number of bronchiectatic lobes (univariable odds ratio [OR], 1.51; 95% confidence interval [CI]; 1.03-2.20; P =. 033) and the presence of ground-glass opacities at chest high-resolution computed tomography (univariable OR, 8.54; 95% CI, 1.04-70.03; P =. 046) predicted HTLV-1 infection. Cor pumonale (HTLV-1-positive group, 10/52; HTLV-1-negative group, 1/37; P =. 023) was more frequent among HTLV-1-seropositive adults, who also experienced a higher disease-specific mortality (univariable OR, 5.78; 95% CI, 1.17-26.75; P =. 028). Only HTLV-1-seropositive patients were admitted specifically for the treatment of infected skin lesions, and this finding predicted death (multivariable OR, 6.77; 95% CI, 1.46-31.34; P =. 014). Overall mortality was high; 34.2% of the cohort died at a median age of 42.5 years. Conclusions. HTLV-1 infection contributes to the risk of developing bronchiectasis and worsens outcomes among Indigenous Australians. | en_US |
dc.language.iso | eng | |
dc.publisher | Oxford University Press | |
dc.relation.ispartofseries | Clinical Infectious Diseases | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Humans | en_US |
dc.subject | Cohort Studies | en_US |
dc.subject | Controlled Study | en_US |
dc.subject | Population Research | en_US |
dc.subject | Disease Association | en_US |
dc.subject | Infant | en_US |
dc.subject | Retrospective Studies | en_US |
dc.subject | School |Mortality | en_US |
dc.subject | HTLV-I Infections | en_US |
dc.subject | Human T Cell Leukemia Virus 1 | en_US |
dc.subject | Human T-Lymphotropic Virus 1 | en_US |
dc.subject | Treatment Outcome | en_US |
dc.subject | Survival Analysis | en_US |
dc.subject | Outcome Assessment | en_US |
dc.subject | Computer Assisted Tomography | en_US |
dc.subject | Skin Defect | en_US |
dc.subject | Population Groups | en_US |
dc.subject | Australia | en_US |
dc.subject | Bronchiectasis | en_US |
dc.subject | Cor Pulmonale | en_US |
dc.subject | Human T Cell Leukemia Virus 1 Infection | en_US |
dc.subject | Retrovirus Infection | en_US |
dc.title | Bronchiectasis is associated with human T-lymphotropic virus 1 infection in an Indigenous Australian population | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1093/cid/cir766 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.08 | |
dc.relation.issn | 1537-6591 |
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