Universidad Peruana Cayetano Heredia

Bronchiectasis is associated with human T-lymphotropic virus 1 infection in an Indigenous Australian population

Mostrar el registro sencillo del ítem

dc.contributor.author Einsiedel, L.
dc.contributor.author Fernandes, L.
dc.contributor.author Spelman, T.
dc.contributor.author Steinfort, D.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2022-01-18T19:26:51Z
dc.date.available 2022-01-18T19:26:51Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10946
dc.description.abstract Background. Recent studies suggest that infection with human T-lymphotropic virus 1 (HTLV-1) might be associated with bronchiectasis among Indigenous Australians. The present study compared the clinical characteristics and outcomes of bronchiectasis in this population, according to HTLV-1 serologic status. Methods. We performed a retrospective cohort study of Indigenous adults with bronchiectasis and known HTLV-1 serologic status admitted to Alice Springs Hospital, central Australia, from January 2000 through December 2006. Results. Among 89 Indigenous adults whose HTLV-1 serologic status was confirmed, 52 (58.4%) were HTLV-1 seropositive. Differences between HTLV-1-seropositive and HTLV-1-seronegative groups were apparent in childhood presentations and adult outcomes. Among adults, an increasing number of bronchiectatic lobes (univariable odds ratio [OR], 1.51; 95% confidence interval [CI]; 1.03-2.20; P =. 033) and the presence of ground-glass opacities at chest high-resolution computed tomography (univariable OR, 8.54; 95% CI, 1.04-70.03; P =. 046) predicted HTLV-1 infection. Cor pumonale (HTLV-1-positive group, 10/52; HTLV-1-negative group, 1/37; P =. 023) was more frequent among HTLV-1-seropositive adults, who also experienced a higher disease-specific mortality (univariable OR, 5.78; 95% CI, 1.17-26.75; P =. 028). Only HTLV-1-seropositive patients were admitted specifically for the treatment of infected skin lesions, and this finding predicted death (multivariable OR, 6.77; 95% CI, 1.46-31.34; P =. 014). Overall mortality was high; 34.2% of the cohort died at a median age of 42.5 years. Conclusions. HTLV-1 infection contributes to the risk of developing bronchiectasis and worsens outcomes among Indigenous Australians. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Clinical Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Cohort Studies en_US
dc.subject Controlled Study en_US
dc.subject Population Research en_US
dc.subject Disease Association en_US
dc.subject Infant en_US
dc.subject Retrospective Studies en_US
dc.subject School |Mortality en_US
dc.subject HTLV-I Infections en_US
dc.subject Human T Cell Leukemia Virus 1 en_US
dc.subject Human T-Lymphotropic Virus 1 en_US
dc.subject Treatment Outcome en_US
dc.subject Survival Analysis en_US
dc.subject Outcome Assessment en_US
dc.subject Computer Assisted Tomography en_US
dc.subject Skin Defect en_US
dc.subject Population Groups en_US
dc.subject Australia en_US
dc.subject Bronchiectasis en_US
dc.subject Cor Pulmonale en_US
dc.subject Human T Cell Leukemia Virus 1 Infection en_US
dc.subject Retrovirus Infection en_US
dc.title Bronchiectasis is associated with human T-lymphotropic virus 1 infection in an Indigenous Australian population en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/cid/cir766
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6591


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas