dc.contributor.author |
Montes Delgado, Martin |
|
dc.contributor.author |
Sanchez, C. |
|
dc.contributor.author |
Lewis, D.E. |
|
dc.contributor.author |
Graviss, E.A. |
|
dc.contributor.author |
Seas Ramos, Carlos Rafael |
|
dc.contributor.author |
Gotuzzo Herencia, José Eduardo |
|
dc.contributor.author |
White Jr., A.C. |
|
dc.date.accessioned |
2022-01-18T19:26:51Z |
|
dc.date.available |
2022-01-18T19:26:51Z |
|
dc.date.issued |
2011 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/10949 |
|
dc.description.abstract |
Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4+CD25+FoxP3+ T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4+CD25+FoxP3+ cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Oxford University Press |
|
dc.relation.ispartofseries |
Journal of Infectious Diseases |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Humans |
en_US |
dc.subject |
Drug Efficacy |
en_US |
dc.subject |
HIV Infections |
en_US |
dc.subject |
Human Immunodeficiency Virus Infection |
en_US |
dc.subject |
Clinical |Peripheral Blood Mononuclear Cell |
en_US |
dc.subject |
Virus Load |
en_US |
dc.subject |
CD4 Lymphocyte Count |
en_US |
dc.subject |
Highly Active Antiretroviral Therapy |
en_US |
dc.subject |
Treatment Response |
en_US |
dc.subject |
Antiretroviral Therapy Highly Active |
en_US |
dc.subject |
Anti-HIV Agents |
en_US |
dc.subject |
Regulatory T Lymphocyte |
en_US |
dc.subject |
Transcription Factor FOXP3 |
en_US |
dc.subject |
RNA Directed DNA Polymerase Inhibitor |
en_US |
dc.subject |
CD4+ CD25+ T Lymphocyte |
en_US |
dc.subject |
Forkhead Transcription Factors |
en_US |
dc.subject |
Interleukin-2 Receptor Alpha Subunit |
en_US |
dc.subject |
T-Lymphocytes Regulatory |
en_US |
dc.subject |
Lymphocyte Count |
en_US |
dc.subject |
Antigens CD4 |
en_US |
dc.subject |
Nonnucleoside Reverse Transcriptase Inhibitor |
en_US |
dc.title |
Normalization of FoxP3+ regulatory T cells in response to effective antiretroviral therapy |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1093/infdis/jiq073 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.03.08 |
|
dc.relation.issn |
1537-6613 |
|