Universidad Peruana Cayetano Heredia

Normalization of FoxP3+ regulatory T cells in response to effective antiretroviral therapy

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dc.contributor.author Montes Delgado, Martin
dc.contributor.author Sanchez, C.
dc.contributor.author Lewis, D.E.
dc.contributor.author Graviss, E.A.
dc.contributor.author Seas Ramos, Carlos Rafael
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author White Jr., A.C.
dc.date.accessioned 2022-01-18T19:26:51Z
dc.date.available 2022-01-18T19:26:51Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10949
dc.description.abstract Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4+CD25+FoxP3+ T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4+CD25+FoxP3+ cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Drug Efficacy en_US
dc.subject HIV Infections en_US
dc.subject Human Immunodeficiency Virus Infection en_US
dc.subject Clinical |Peripheral Blood Mononuclear Cell en_US
dc.subject Virus Load en_US
dc.subject CD4 Lymphocyte Count en_US
dc.subject Highly Active Antiretroviral Therapy en_US
dc.subject Treatment Response en_US
dc.subject Antiretroviral Therapy Highly Active en_US
dc.subject Anti-HIV Agents en_US
dc.subject Regulatory T Lymphocyte en_US
dc.subject Transcription Factor FOXP3 en_US
dc.subject RNA Directed DNA Polymerase Inhibitor en_US
dc.subject CD4+ CD25+ T Lymphocyte en_US
dc.subject Forkhead Transcription Factors en_US
dc.subject Interleukin-2 Receptor Alpha Subunit en_US
dc.subject T-Lymphocytes Regulatory en_US
dc.subject Lymphocyte Count en_US
dc.subject Antigens CD4 en_US
dc.subject Nonnucleoside Reverse Transcriptase Inhibitor en_US
dc.title Normalization of FoxP3+ regulatory T cells in response to effective antiretroviral therapy en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/infdis/jiq073
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6613


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