Universidad Peruana Cayetano Heredia

Small qnrB-harbouring ColE-like plasmids widespread in commensal enterobacteria from a remote Amazonas population not exposed to antibiotics

Mostrar el registro sencillo del ítem

dc.contributor.author Pallecchi, L.
dc.contributor.author Riccobono, E.
dc.contributor.author Mantella, A.
dc.contributor.author Fernandez, C.
dc.contributor.author Bartalesi, F.
dc.contributor.author Rodriguez, H.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Bartoloni, A.
dc.contributor.author Rossolini, G.M.
dc.date.accessioned 2022-01-18T19:26:51Z
dc.date.available 2022-01-18T19:26:51Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10951
dc.description.abstract Sir, After a decade since discovery, a variety of qnr-type plasmid-mediated quinolone resistance genes have been reported worldwide, especially in clinical isolates of Enterobacteriaceae.1 Recently, we found that qnr genes (mostly qnrB) were highly prevalent among commensal enterobacteria from healthy children living in resource-limited urban settings of Latin America.2 This unexpected finding could not be directly related with quinolone use, since these drugs are not prescribed in childhood. We then speculated that it could reflect a sustained adults-to-children transmission of enterobacteria within households (favoured by crowding and poor hygienic standards) and, possibly, a co-selection of the qnr-harbouring plasmids due to the presence of linked resistance determinants to antibiotics that are used in children. The latter explanation, however, was ruled out for the most prevalent qnr gene (qnrB19), whose dissemination was found to be related to a broad and interspecific diffusion of two small ColE-like plasmids harbouring this gene as the sole resistance determinant (plasmids pECC14-9 of 3.0 kb and pECY6-7 of 2.7 kb).3 Similar small QnrB19-encoding ColE-like plasmids have recently also been identified in various Salmonella enterica serovars of human and animal origin, both in Latin America4 (GenBank accession number GQ412195) and Europe,5 underscoring their role in the international dissemination of qnrB19 in clinical and veterinary settings.... en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Antimicrobial Chemotherapy
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject Nucleotide Sequence en_US
dc.subject Rural Population en_US
dc.subject Letter en_US
dc.subject Bacterial Proteins en_US
dc.subject Anti-Bacterial Agents en_US
dc.subject Bacterial Gene en_US
dc.subject Escherichia Coli en_US
dc.subject Feces Analysis en_US
dc.subject Microbial Sensitivity Tests en_US
dc.subject Bacterium Isolation en_US
dc.subject Bacterial Growth en_US
dc.subject Klebsiella Pneumoniae en_US
dc.subject Commensal en_US
dc.subject Enterobacteriaceae en_US
dc.subject Plasmid en_US
dc.subject Plasmids en_US
dc.subject Drug Resistance Bacterial en_US
dc.subject Antibiotic Agent en_US
dc.subject Escherichia Coli Proteins en_US
dc.subject Random Amplified Polymorphic DNA en_US
dc.subject Commensal Enterobacteriaceae en_US
dc.subject Escherichia en_US
dc.subject Escherichia Fergusonii en_US
dc.subject Faecal Metagenomes en_US
dc.title Small qnrB-harbouring ColE-like plasmids widespread in commensal enterobacteria from a remote Amazonas population not exposed to antibiotics en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/jac/dkr026
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#
dc.relation.issn 1460-2091


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas