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Cardiovascular and renal effects of chronic exposure to high altitude

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dc.contributor.author Hurtado, A.
dc.contributor.author Escudero, E.
dc.contributor.author Pando, J.
dc.contributor.author Sharma, S.
dc.contributor.author Johnson, R.J.
dc.date.accessioned 2022-01-18T19:26:51Z
dc.date.available 2022-01-18T19:26:51Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10954
dc.description.abstract Over 140 million people live at high altitude, defined as living at an altitude of 2400 m or more above sea level. Subjects living under these conditions are continuously living under hypoxic conditions and, depending on the population, various adaptations have developed. Interestingly, subjects living chronically at high altitude appear to have a decreased frequency of obesity, diabetes and coronary artery disease. However, these benefits on health are balanced by the frequent development of systemic and pulmonary hypertension. Recently, it has been recognized that subjects living at high altitude are at risk for developing high-altitude renal syndrome (HARS), which is a syndrome consisting of polycythemia, hyperuricemia, systemic hypertension and microalbuminuria, but with preserved glomerular filtration rate. More studies should be performed to characterize the mechanisms and etiology of HARS; as such studies may be of benefit not only to the high-altitude population, but also to better understanding of the renal consequences of acute and chronic hypoxia. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Nephrology Dialysis Transplantation
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject priority journal en_US
dc.subject review en_US
dc.subject glomerulus filtration rate en_US
dc.subject hypertension en_US
dc.subject incidence en_US
dc.subject kidney disease en_US
dc.subject altitude en_US
dc.subject Altitude en_US
dc.subject long term exposure en_US
dc.subject pulmonary hypertension en_US
dc.subject obesity en_US
dc.subject adaptation en_US
dc.subject Adaptation, Physiological en_US
dc.subject altitude disease en_US
dc.subject hypoxia en_US
dc.subject diabetes mellitus en_US
dc.subject sea level en_US
dc.subject polycythemia en_US
dc.subject kidney function en_US
dc.subject high altitude en_US
dc.subject chronic mountain sickness en_US
dc.subject Kidney Diseases en_US
dc.subject high altitude renal syndrome en_US
dc.subject hyperuricemia en_US
dc.subject microalbuminuria en_US
dc.subject cardiovascular effect en_US
dc.subject coronary artery disease en_US
dc.subject Coronary Disease en_US
dc.subject Heart en_US
dc.title Cardiovascular and renal effects of chronic exposure to high altitude en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1093/ndt/gfs427
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.20
dc.relation.issn 1460-2385


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