Universidad Peruana Cayetano Heredia

Acute and chronic elevation of erythropoietin in the brain improves exercise performance in mice without inducing erythropoiesis

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dc.contributor.author Schuler, B.
dc.contributor.author Vogel, J.
dc.contributor.author Grenacher, B.
dc.contributor.author Jacobs, R.A.
dc.contributor.author Arras, M.
dc.contributor.author Gassmann, M.
dc.date.accessioned 2022-01-18T19:26:51Z
dc.date.available 2022-01-18T19:26:51Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10955
dc.description.abstract Application of recombinant human erythropoietin (rhEpo) improves exercise capacity by stimulating red blood cell production that, in turn, enhances oxygen delivery and utilization. Apart from this, when applied at high doses, rhEpo crosses the blood-brain barrier, triggering protective neuronal effects. Here we show a fundamental new role by which the presence of Epo in the brain augments exercise performance without altering red blood cell production. Two different animal models, the transgenic mouse line Tg21, which constitutively overexpresses human Epo exclusively in the brain without affecting erythropoiesis, and wild-type mice treated with a single high dose of rhEpo, demonstrate an unexpected improvement in maximal exercise performance independent of changes in total hemoglobin mass, as well as in whole blood volume and cardiovascular parameters. This novel finding builds a more complete understanding regarding the central effects of endogenously produced and exogenously applied Epo on exercise performance. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries FASEB Journal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject animal experiment en_US
dc.subject animal tissue en_US
dc.subject Animals en_US
dc.subject Doping en_US
dc.subject exercise en_US
dc.subject hemoglobin en_US
dc.subject Mice en_US
dc.subject mouse en_US
dc.subject non|Physical Conditioning, Animal en_US
dc.subject priority journal en_US
dc.subject drug megadose en_US
dc.subject Arterial Pressure en_US
dc.subject Hemoglobins en_US
dc.subject protein blood level en_US
dc.subject Brain en_US
dc.subject hematocrit en_US
dc.subject wild type en_US
dc.subject Animalia en_US
dc.subject Erythropoiesis en_US
dc.subject Recombinant Proteins en_US
dc.subject Mus en_US
dc.subject erythropoiesis en_US
dc.subject Erythropoietin en_US
dc.subject blood brain barrier en_US
dc.subject brain level en_US
dc.subject brain tissue en_US
dc.subject cardiovascular parameters en_US
dc.subject Cerebral en_US
dc.subject Epo en_US
dc.subject erythrocyte volume en_US
dc.subject Heart Rate en_US
dc.subject Mice, Transgenic en_US
dc.subject Motivation en_US
dc.subject Mus musculus en_US
dc.subject Myocardium en_US
dc.subject Neurotrophic effect en_US
dc.subject recombinant erythropoietin en_US
dc.subject Stroke Volume en_US
dc.title Acute and chronic elevation of erythropoietin in the brain improves exercise performance in mice without inducing erythropoiesis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1096/fj.11-191197
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.11
dc.relation.issn 1530-6860


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