DSpace Repository

Cancer in HIV-infected persons from the caribbean, central and South America

Show simple item record

dc.contributor.author Fink, V.I.
dc.contributor.author Shepherd, B.E.
dc.contributor.author Cesar, C.
dc.contributor.author Krolewiecki, A.
dc.contributor.author Wehbe, F.
dc.contributor.author Cortés, C.P.
dc.contributor.author Ramírez, B.C.-.
dc.contributor.author Padgett, D.
dc.contributor.author Shafaee, M.
dc.contributor.author Schechter, M.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Bacon, M.
dc.contributor.author McGowan, C.
dc.contributor.author Cahn, P.
dc.contributor.author Masys, D.
dc.date.accessioned 2022-01-18T19:26:52Z
dc.date.available 2022-01-18T19:26:52Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10961
dc.description.abstract Background: HIV-infected individuals have heightened cancer risk. With the advent of highly active antiretroviral therapy (HAART), the frequency of some AIDS-defining cancers (ADC) has decreased although certain non-AIDS-defining cancers (NADC) are becoming more frequent. Cancers among HIV-infected individuals in Latin American and the Caribbean have not yet been carefully studied. Methods: Cancer cases among the Caribbean, Central and South American network for HIV Research (CCASAnet) cohort were identified reviewing clinical records and pre-existing databases. Results: There were 406 cancers reported: 331 ADC (224 Kaposi sarcomas and 98 non Hodgkin lymphomas). Most frequent NADC (n = 75) were Hodgkin lymphoma and skin cancers. Seventy-three percent of NADC and 45% of ADC were diagnosed >1 year after HIV diagnosis. Fifty-six percent of ADC occurred before HAART start. Median time from HAART start until cancer diagnosis was 2.5 years for NADC and 0.5 years for ADC (P = <0.001). Within 3372 HAART starters, 158 were diagnosed with 165 cancers (82.4% ADC); 85 cases were previous to or concomitant with HAART initiation. Incidence of cancer after HAART initiation in 8080 person-years of follow-up was 7.2 per 1000 person-years (95% confidence interval = 5.5 to 9.3) for ADC and 2.7 (95% confidence interval = 1.8 to 4.1) for NADC; incidence was higher in the first 2 months, particularly for ADC (47.6). A pre-HAART ADC was a predictor of mortality after adjusting for age, sex, and CD4 at HAART initiation. Conclusions: ADC were the most frequent cancers in this region and were often diagnosed close to HIV diagnosis and HAART start. Incidence of cancer was highest around HAART initiation. . en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries Journal of Acquired Immune Deficiency Syndromes
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Major Clinical Study en_US
dc.subject Central America en_US
dc.subject South America en_US
dc.subject Latin America en_US
dc.subject Uterine Cervix Carcinoma In Situ en_US
dc.subject Human Immunodeficiency Virus Infection en_US
dc.subject HIV en_US
dc.subject Histopathology en_US
dc.subject Cytology en_US
dc.subject Human Immunodeficiency Virus Infected Patient en_US
dc.subject Highly Active Antiretroviral Therapy en_US
dc.subject Melanoma en_US
dc.subject Neoplasm en_US
dc.subject Breast Cancer en_US
dc.subject Uterine Cervix Carcinoma en_US
dc.subject Lung Cancer en_US
dc.subject Cohort Studies en_US
dc.subject Caribbean en_US
dc.subject Kaposi Sarcoma en_US
dc.subject Medical Record Review en_US
dc.subject Caribbean Islands en_US
dc.subject Anus Cancer en_US
dc.subject Cancer Diagnosis en_US
dc.subject Hodgkin Disease en_US
dc.subject Neoplasms en_US
dc.subject Nonhodgkin Lymphoma en_US
dc.subject Prostate Cancer en_US
dc.subject Skin Cancer en_US
dc.subject Testis Cancer en_US
dc.title Cancer in HIV-infected persons from the caribbean, central and South America en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1097/QAI.0b013e31820bb1c3
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 1944-7884


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics