Universidad Peruana Cayetano Heredia

Cancer in HIV-infected persons from the caribbean, central and South America

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dc.contributor.author Fink, V.I.
dc.contributor.author Shepherd, B.E.
dc.contributor.author Cesar, C.
dc.contributor.author Krolewiecki, A.
dc.contributor.author Wehbe, F.
dc.contributor.author Cortés, C.P.
dc.contributor.author Ramírez, B.C.-.
dc.contributor.author Padgett, D.
dc.contributor.author Shafaee, M.
dc.contributor.author Schechter, M.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Bacon, M.
dc.contributor.author McGowan, C.
dc.contributor.author Cahn, P.
dc.contributor.author Masys, D.
dc.date.accessioned 2022-01-18T19:26:52Z
dc.date.available 2022-01-18T19:26:52Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10961
dc.description.abstract Background: HIV-infected individuals have heightened cancer risk. With the advent of highly active antiretroviral therapy (HAART), the frequency of some AIDS-defining cancers (ADC) has decreased although certain non-AIDS-defining cancers (NADC) are becoming more frequent. Cancers among HIV-infected individuals in Latin American and the Caribbean have not yet been carefully studied. Methods: Cancer cases among the Caribbean, Central and South American network for HIV Research (CCASAnet) cohort were identified reviewing clinical records and pre-existing databases. Results: There were 406 cancers reported: 331 ADC (224 Kaposi sarcomas and 98 non Hodgkin lymphomas). Most frequent NADC (n = 75) were Hodgkin lymphoma and skin cancers. Seventy-three percent of NADC and 45% of ADC were diagnosed >1 year after HIV diagnosis. Fifty-six percent of ADC occurred before HAART start. Median time from HAART start until cancer diagnosis was 2.5 years for NADC and 0.5 years for ADC (P = <0.001). Within 3372 HAART starters, 158 were diagnosed with 165 cancers (82.4% ADC); 85 cases were previous to or concomitant with HAART initiation. Incidence of cancer after HAART initiation in 8080 person-years of follow-up was 7.2 per 1000 person-years (95% confidence interval = 5.5 to 9.3) for ADC and 2.7 (95% confidence interval = 1.8 to 4.1) for NADC; incidence was higher in the first 2 months, particularly for ADC (47.6). A pre-HAART ADC was a predictor of mortality after adjusting for age, sex, and CD4 at HAART initiation. Conclusions: ADC were the most frequent cancers in this region and were often diagnosed close to HIV diagnosis and HAART start. Incidence of cancer was highest around HAART initiation. . en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries Journal of Acquired Immune Deficiency Syndromes
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Major Clinical Study en_US
dc.subject Central America en_US
dc.subject South America en_US
dc.subject Latin America en_US
dc.subject Uterine Cervix Carcinoma In Situ en_US
dc.subject Human Immunodeficiency Virus Infection en_US
dc.subject HIV en_US
dc.subject Histopathology en_US
dc.subject Cytology en_US
dc.subject Human Immunodeficiency Virus Infected Patient en_US
dc.subject Highly Active Antiretroviral Therapy en_US
dc.subject Melanoma en_US
dc.subject Neoplasm en_US
dc.subject Breast Cancer en_US
dc.subject Uterine Cervix Carcinoma en_US
dc.subject Lung Cancer en_US
dc.subject Cohort Studies en_US
dc.subject Caribbean en_US
dc.subject Kaposi Sarcoma en_US
dc.subject Medical Record Review en_US
dc.subject Caribbean Islands en_US
dc.subject Anus Cancer en_US
dc.subject Cancer Diagnosis en_US
dc.subject Hodgkin Disease en_US
dc.subject Neoplasms en_US
dc.subject Nonhodgkin Lymphoma en_US
dc.subject Prostate Cancer en_US
dc.subject Skin Cancer en_US
dc.subject Testis Cancer en_US
dc.title Cancer in HIV-infected persons from the caribbean, central and South America en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1097/QAI.0b013e31820bb1c3
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 1944-7884


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