Universidad Peruana Cayetano Heredia

Phylogenetic relationships of Shiga toxin-producing Escherichia coli isolated from Peruvian children

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dc.contributor.author Contreras, C.A.
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Ruiz, J.
dc.contributor.author Lacher, D.W.
dc.contributor.author Rivera, F.P.
dc.contributor.author Saenz, Y.
dc.contributor.author Chea-Woo, E.
dc.contributor.author Zavaleta, N.
dc.contributor.author Gil, A.I.
dc.contributor.author Lanata, C.F.
dc.contributor.author Huicho Oriundo, Luis
dc.contributor.author Maves, R.C.
dc.contributor.author Torres, C.
dc.contributor.author DebRoy, C.
dc.contributor.author Cleary, T.G.
dc.date.accessioned 2022-01-18T19:26:52Z
dc.date.available 2022-01-18T19:26:52Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10967
dc.description.abstract The aim of this study was to determine the prevalence, virulence factors (stx, eae, ehxA and astA) and phylogenetic relationships [PFGE and multilocus sequence typing (MLST)] of Shiga toxinproducing Escherichia coli (STEC) strains isolated from four previous cohort studies in 2212 Peruvian children aged,36 months. STEC prevalence was 0.4% (14/3219) in diarrhoeal and 0.6% (15/2695) in control samples. None of the infected children developed haemolytic uraemic syndrome (HUS) or other complications of STEC. stx1 was present in 83% of strains, stx2 in 17%, eae in 72%, ehxA in 59% and astA in 14%. The most common serotype was O26: H11 (14%) and the most common seropathotype was B (45%). The strains belonged mainly to phylogenetic group B1 (52%). The distinct combinations of alleles across the seven MLST loci were used to define 13 sequence types among 19 STEC strains. PFGE typing of 20 STEC strains resulted in 19 pulsed-field patterns. Comparison of the patterns revealed 11 clusters (I-XI), each usually including strains belonging to different serotypes; one exception was cluster VI, which gathered exclusively seven strains of seropathotype B, clonal group enterohaemorrhagic E. coli (EHEC) 2 and phylogenetic group B1. In summary, STEC prevalence was low in Peruvian children with diarrhea in the community setting. The strains were phylogenetically diverse and associated with mild infections. However, additional studies are needed in children with bloody diarrhoea and HUS. en_US
dc.language.iso eng
dc.publisher Microbiology Society
dc.relation.ispartofseries Journal of Medical Microbiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Case-Control Studies en_US
dc.subject child en_US
dc.subject Child, Preschool en_US
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject preschool child en_US
dc.subject article en_US
dc.subject Cohort Studies en_US
dc.subject non|priority journal en_US
dc.subject phylogeny en_US
dc.subject unclassified drug en_US
dc.subject Infant en_US
dc.subject Prevalence en_US
dc.subject diarrhea en_US
dc.subject infant en_US
dc.subject Infant, Newborn en_US
dc.subject DNA, Bacterial en_US
dc.subject Base Sequence en_US
dc.subject Electrophoresis, Gel, Pulsed-Field en_US
dc.subject Serotyping en_US
dc.subject Escherichia coli Infections en_US
dc.subject Virulence Factors en_US
dc.subject enterotoxigenic Escherichia coli en_US
dc.subject Escherichia coli infection en_US
dc.subject Phylogeny en_US
dc.subject serotype en_US
dc.subject bacterial virulence en_US
dc.subject enteropathogenic Escherichia coli en_US
dc.subject virulence factor en_US
dc.subject Genes, Bacterial en_US
dc.subject Multilocus Sequence Typing en_US
dc.subject enteroaggregative Escherichia coli en_US
dc.subject Escherichia coli Proteins en_US
dc.subject Shiga toxin producing Escherichia coli en_US
dc.subject Shiga-Toxigenic Escherichia coli en_US
dc.subject multilocus sequence typing en_US
dc.subject Adhesins, Bacterial en_US
dc.subject astA protein en_US
dc.subject chuA protein en_US
dc.subject eae protein en_US
dc.subject ehxA protein en_US
dc.subject enterohemorrhagic Escherichia coli en_US
dc.subject Escherichia coli protein en_US
dc.subject Hemolysin Proteins en_US
dc.subject Shiga Toxin en_US
dc.subject stx protein en_US
dc.subject tspE protein en_US
dc.subject yjaA protein en_US
dc.title Phylogenetic relationships of Shiga toxin-producing Escherichia coli isolated from Peruvian children en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1099/jmm.0.026666-0
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#
dc.relation.issn 1473-5644


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