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Effect of the ethanolic extract from Fagara tessmannii on testicular function, sex reproductive organs and hormone level in adult male rats

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dc.contributor.author Massoma Lembè, D.
dc.contributor.author Gasco Tantachuco, Manuel Enrique
dc.contributor.author Rubio, J.
dc.contributor.author Yucra, S.
dc.contributor.author Ngo Sock, E.
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2022-01-18T19:26:52Z
dc.date.available 2022-01-18T19:26:52Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10977
dc.description.abstract The effect of ethanolic extract of Fagara tessmannii, wide medicinal plants used on reproductive function in South Cameroon, was investigated in male rats. Twenty male sexually experienced rats (four groups) were orally treated with vehicle, 0.01, 0.1, 1gkg -1 BW per day of F. tessmannii (equivalent to 16.67g, 33.33g, 50g, 66.66gkg -1 dry raw material) for 14days, the upper limit dose without any clinical sign of toxicity was 2gkg -1 . Fagara tessmannii extract negatively affected weight of accessory organs and significantly affected body weight gain at dose 1gkg -1 (P<0.05) in treated rats. The weight of epididymis and seminal vesicle significantly decreased at low doses (0.01gkg -1 ) while the prostate weight decreased at all doses (P<0.05). The transit of spermatozoa in cauda epididymidis significantly increased at lower dose of 0.01gkg -1 (P<0.05). In addition, F. tessmannii extract affected neither daily sperm production (DSP) and DSP per g nor sperm count in vas deferens and epididymis. The length of stages IX-I of the seminiferous tubule and serum testosterone level increased dose-dependently following 14days of treatment (P<0.05). The results suggest that F. tessmannii, 14days after treatment, may improve spermatogenesis, testosterone level and sperm transit in cauda epididymidis but negatively impair reproductive organ activities. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Andrologia
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject controlled study en_US
dc.subject animal experiment en_US
dc.subject non|unclassified drug en_US
dc.subject weight gain en_US
dc.subject drug effect en_US
dc.subject plant extract en_US
dc.subject rat en_US
dc.subject spermatogenesis en_US
dc.subject spermatozoon count en_US
dc.subject seminal vesicle en_US
dc.subject testosterone en_US
dc.subject Testosterone en_US
dc.subject testosterone blood level en_US
dc.subject epididymis tail en_US
dc.subject Fagara tessmannii en_US
dc.subject Fagara tessmannii extract en_US
dc.subject seminiferous tubule en_US
dc.subject Spermatogenesis en_US
dc.subject spermatozoon en_US
dc.subject testis function en_US
dc.title Effect of the ethanolic extract from Fagara tessmannii on testicular function, sex reproductive organs and hormone level in adult male rats en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/j.1439-0272.2009.01035.x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.01
dc.relation.issn 1439-0272


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