Serum testosterone levels and score of chronic mountain sickness in Peruvian men natives at 4340m

Gonzales Rengifo, Gustavo Francisco; Gonzales-Castañeda, C.; Gasco Tantachuco, Manuel Enrique; Tapia Aguirre, Vilma Lucrecia

dc.contributor.author	Gonzales Rengifo, Gustavo Francisco
dc.contributor.author	Tapia Aguirre, Vilma Lucrecia
dc.contributor.author	Gasco Tantachuco, Manuel Enrique
dc.contributor.author	Gonzales-Castañeda, C.
dc.date.accessioned	2022-01-18T19:26:52Z
dc.date.available	2022-01-18T19:26:52Z
dc.date.issued	2011
dc.identifier.uri	https://hdl.handle.net/20.500.12866/10978
dc.description.abstract	Life at high altitudes (>4000m) is associated with higher erythropoiesis. Haemoglobin ≥21gdl-1 is considered as excessive erythrocytosis and is a sign of chronic mountain sickness (CMS). The present study was designed to determine an association between serum testosterone (T) and serum oestradiol (E2) levels with the score of CMS. One hundred and seventeen men natives from low altitude (150m) and 103 men natives from high altitude (4340m) were studied. The presence of breathlessness or palpitations, sleep disturbance, cyanosis, dilatation of veins, paraesthesia, headaches, tinnitus and Hb ≥21gdl-1, have been included for the CMS score. Men living at high altitude had higher CMS score (P<0.001), serum T (P<0.05) and serum E2 levels (P<0.04) and had lower serum luteinising hormone levels (P<0.005) than men living at sea level. At high altitude, the group with the highest CMS score (≥10) showed higher chronological age, SpO2, serum T and ratio T/E2 than the group with CMS score of ≤4. Some symptoms of CMS as sleep disorders and paraesthesia were more related to high serum T level; cyanosis was more related to higher haemoglobin values. In conclusion, higher serum T levels were associated to higher scores of CMS.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Andrologia
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Humans	en_US
dc.subject	Peru	en_US
dc.subject	Major Clinical Study	en_US
dc.subject	Headache	en_US
dc.subject	Altitude	en_US
dc.subject	Altitude Disease	en_US
dc.subject	Altitude Sickness	en_US
dc.subject	Groups By Age	en_US
dc.subject	Dyspnea	en_US
dc.subject	Ethnic Group	en_US
dc.subject	Hemoglobin Blood Level	en_US
dc.subject	Testosterone	en_US
dc.subject	Chronic Mountain Sickness	en_US
dc.subject	Correlation Analysis	en_US
dc.subject	Cyanosis	en_US
dc.subject	Estradiol Blood Level	en_US
dc.subject	Excessive Erythrocytosis	en_US
dc.subject	Heart Palpitation	en_US
dc.subject	Luteinizing Hormone Blood Level	en_US
dc.subject	Men	en_US
dc.subject	Oxygen Saturation	en_US
dc.subject	Oxygen Tension	en_US
dc.subject	Paresthesia	en_US
dc.subject	Scoring System	en_US
dc.subject	Sea Level	en_US
dc.subject	Sex Steroids	en_US
dc.subject	Sleep Disorder	en_US
dc.subject	Symptomatology	en_US
dc.subject	Testosterone Blood Level	en_US
dc.subject	Tinnitus	en_US
dc.subject	Vasodilatation	en_US
dc.title	Serum testosterone levels and score of chronic mountain sickness in Peruvian men natives at 4340m	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1111/j.1439-0272.2010.01046.x
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.01
dc.relation.issn	1439-0272