Evaluation of different doses of mashua (Tropaeolum tuberosum) on the reduction of sperm production, motility and morphology in adult male rats.

Rubio, J.; Leiva-Revilla, J.; Gasco Tantachuco, Manuel Enrique; Guerra-Castañón, F.; Gonzales Rengifo, Gustavo Francisco; Cárdenas-Valencia, I.; Olcese-Mori, P.

dc.contributor.author	Leiva-Revilla, J.
dc.contributor.author	Cárdenas-Valencia, I.
dc.contributor.author	Rubio, J.
dc.contributor.author	Guerra-Castañón, F.
dc.contributor.author	Olcese-Mori, P.
dc.contributor.author	Gasco Tantachuco, Manuel Enrique
dc.contributor.author	Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned	2022-01-18T19:26:52Z
dc.date.available	2022-01-18T19:26:52Z
dc.date.issued	2012
dc.identifier.uri	https://hdl.handle.net/20.500.12866/10979
dc.description.abstract	Mashua is an edible-tuber crop that grows in the Andean region. Folk medicine describes the use of mashua to reduce reproductive function in men. The present study aimed: (i) to determine whether different doses of mashua (0.01, 0.1, 1 and 2 g kg(-1)) produced a dose-response reduction on sperm production and quality; and, (ii) to determine whether these anti-reproductive effects of mashua can be reversible after cessation of treatment (12 and 24 days of recovery time). Mashua-treated rats showed lower values of daily sperm production, epididymal and vas deferens sperm count and sperm motility; meanwhile, mashua increased the percentage of abnormal sperm morphology and epididymal sperm transit rate. The following variables follow a dose-response effect: sperm number in vas deferens, sperm motility and sperm transit rate. In addition, it was demonstrated that the reduction in reproduction function in male rats treated with mashua was reversible after 24 days of recovery time. Finally, lower doses mashua reduces sperm number and quality (motility and morphology), and these adverse effects on male reproductive system may be reversible after 24 days after cessation of the treatment.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Andrologia
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	animal experiment	en_US
dc.subject	Animals	en_US
dc.subject	non\|morphology	en_US
dc.subject	unclassified drug	en_US
dc.subject	dose response	en_US
dc.subject	reproduction	en_US
dc.subject	Daily sperm production	en_US
dc.subject	Dose-Response Relationship, Drug	en_US
dc.subject	Epididymal sperm transit	en_US
dc.subject	epididymis	en_US
dc.subject	male genital system	en_US
dc.subject	Mashua	en_US
dc.subject	plant extract	en_US
dc.subject	Plant Extracts	en_US
dc.subject	rat	en_US
dc.subject	Rats	en_US
dc.subject	Rats, Sprague-Dawley	en_US
dc.subject	Sperm Count	en_US
dc.subject	Sperm Motility	en_US
dc.subject	Sperm motility and morphology	en_US
dc.subject	Sperm number	en_US
dc.subject	spermatogenesis	en_US
dc.subject	Spermatozoa	en_US
dc.subject	spermatozoon count	en_US
dc.subject	spermatozoon motility	en_US
dc.subject	Tropaeolaceae	en_US
dc.subject	Tropaeolum	en_US
dc.subject	Tropaeolum tuberosum extract	en_US
dc.subject	vas deferens	en_US
dc.title	Evaluation of different doses of mashua (Tropaeolum tuberosum) on the reduction of sperm production, motility and morphology in adult male rats.	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1111/j.1439-0272.2011.01165.x
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.01
dc.relation.issn	1439-0272