Universidad Peruana Cayetano Heredia

Evaluation of different doses of mashua (Tropaeolum tuberosum) on the reduction of sperm production, motility and morphology in adult male rats.

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dc.contributor.author Leiva-Revilla, J.
dc.contributor.author Cárdenas-Valencia, I.
dc.contributor.author Rubio, J.
dc.contributor.author Guerra-Castañón, F.
dc.contributor.author Olcese-Mori, P.
dc.contributor.author Gasco Tantachuco, Manuel Enrique
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2022-01-18T19:26:52Z
dc.date.available 2022-01-18T19:26:52Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10979
dc.description.abstract Mashua is an edible-tuber crop that grows in the Andean region. Folk medicine describes the use of mashua to reduce reproductive function in men. The present study aimed: (i) to determine whether different doses of mashua (0.01, 0.1, 1 and 2 g kg(-1)) produced a dose-response reduction on sperm production and quality; and, (ii) to determine whether these anti-reproductive effects of mashua can be reversible after cessation of treatment (12 and 24 days of recovery time). Mashua-treated rats showed lower values of daily sperm production, epididymal and vas deferens sperm count and sperm motility; meanwhile, mashua increased the percentage of abnormal sperm morphology and epididymal sperm transit rate. The following variables follow a dose-response effect: sperm number in vas deferens, sperm motility and sperm transit rate. In addition, it was demonstrated that the reduction in reproduction function in male rats treated with mashua was reversible after 24 days of recovery time. Finally, lower doses mashua reduces sperm number and quality (motility and morphology), and these adverse effects on male reproductive system may be reversible after 24 days after cessation of the treatment. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Andrologia
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject animal experiment en_US
dc.subject Animals en_US
dc.subject non|morphology en_US
dc.subject unclassified drug en_US
dc.subject dose response en_US
dc.subject reproduction en_US
dc.subject Daily sperm production en_US
dc.subject Dose-Response Relationship, Drug en_US
dc.subject Epididymal sperm transit en_US
dc.subject epididymis en_US
dc.subject male genital system en_US
dc.subject Mashua en_US
dc.subject plant extract en_US
dc.subject Plant Extracts en_US
dc.subject rat en_US
dc.subject Rats en_US
dc.subject Rats, Sprague-Dawley en_US
dc.subject Sperm Count en_US
dc.subject Sperm Motility en_US
dc.subject Sperm motility and morphology en_US
dc.subject Sperm number en_US
dc.subject spermatogenesis en_US
dc.subject Spermatozoa en_US
dc.subject spermatozoon count en_US
dc.subject spermatozoon motility en_US
dc.subject Tropaeolaceae en_US
dc.subject Tropaeolum en_US
dc.subject Tropaeolum tuberosum extract en_US
dc.subject vas deferens en_US
dc.title Evaluation of different doses of mashua (Tropaeolum tuberosum) on the reduction of sperm production, motility and morphology in adult male rats. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/j.1439-0272.2011.01165.x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.01
dc.relation.issn 1439-0272


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