Universidad Peruana Cayetano Heredia

Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone-induced prostatic hyperplasia.

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dc.contributor.author Gonzales Arimborgo, Carla Jeannine
dc.contributor.author Leiva-Revilla, J.
dc.contributor.author Rubio, J.
dc.contributor.author Gasco Tantachuco, Manuel Enrique
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2022-01-18T19:26:52Z
dc.date.available 2022-01-18T19:26:52Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10980
dc.description.abstract Lepidium meyenii (maca) is a plant that grows exclusively above 4000 m in the Peruvian central Andes. Red maca (RM) extract significantly reduced prostate size in rats with benign prostatic hyperplasia (BPH) induced by testosterone enanthate (TE). Zinc is an important regulator of prostate function. This study aimed to determine the effect of RM on prostate zinc levels in rats with BPH induced by TE. Also, the study attempted to determine the best marker for the effect of RM on sex accessory glands. Rats treated with RM extract from day 1 to day 14 reversed the effect of TE administration on prostate weight and zinc levels. However, RM administered from day 7 to day 14 did not reduce the effect of TE on all studied variables. Finasteride (FN) reduced prostate, seminal vesicle and preputial gland weights in rats treated with TE. Although RM and FN reduced prostate zinc levels, the greatest effect was observed in TE-treated rats with RM from day 1 to day 14. In addition, prostate weight and zinc levels showed the higher diagnosis values than preputial and seminal vesicle weights. In conclusion, RM administered from day 1 to day 14 reduced prostate size and zinc levels in rats where prostatic hyperplasia was induced with TE. Also, this experimental model could be used as accurately assay to determine the effect of maca obtained under different conditions and/or the effect of different products based on maca. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Andrologia
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject animal model en_US
dc.subject Animals en_US
dc.subject non|Plant Extracts en_US
dc.subject Rats en_US
dc.subject Rats, Sprague-Dawley en_US
dc.subject Finasteride en_US
dc.subject Lepidium en_US
dc.subject Lepidium meyenii extract en_US
dc.subject medicinal plant en_US
dc.subject Organ Size en_US
dc.subject organ weight en_US
dc.subject Preputial gland en_US
dc.subject prostate en_US
dc.subject Prostate en_US
dc.subject prostate hypertrophy en_US
dc.subject prostate weight en_US
dc.subject Prostate weight en_US
dc.subject prostate zinc level en_US
dc.subject Prostatic Hyperplasia en_US
dc.subject Prostatic zinc levels en_US
dc.subject Red maca en_US
dc.subject Seminal vesicle en_US
dc.subject Testosterone en_US
dc.subject tissue level en_US
dc.subject Zinc en_US
dc.title Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone-induced prostatic hyperplasia. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/j.1439-0272.2011.01190.x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.01
dc.relation.issn 1439-0272


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