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Expression of fatty acid synthase (FASN) in oral nevi and melanoma

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dc.contributor.author De Andrade, B.
dc.contributor.author León, J. E.
dc.contributor.author Carlos, R.
dc.contributor.author Delgado-Azañero, W.
dc.contributor.author Mosqueda-Taylor, A.
dc.contributor.author Graner, E.
dc.contributor.author de Almeida, O.
dc.date.accessioned 2022-01-18T19:26:53Z
dc.date.available 2022-01-18T19:26:53Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10986
dc.description.abstract The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions. Materials and Methods: Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas. Results: Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression. Conclusion: Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Oral Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject protein expression en_US
dc.subject human tissue en_US
dc.subject Skin Neoplasms en_US
dc.subject Tumor Markers, Biological en_US
dc.subject Immunohistochemistry en_US
dc.subject melanocytic nevus en_US
dc.subject Melanoma en_US
dc.subject Mouth Neoplasms en_US
dc.subject Nevus, Pigmented en_US
dc.subject Mouth Mucosa en_US
dc.subject Antibodies en_US
dc.subject Coloring Agents en_US
dc.subject Nevus en_US
dc.subject Fatty acid synthase en_US
dc.subject Fatty Acid Synthetase Complex en_US
dc.subject Melanocytes en_US
dc.subject Melanocytic nevi en_US
dc.subject Mouth en_US
dc.subject Nevus, Intradermal en_US
dc.title Expression of fatty acid synthase (FASN) in oral nevi and melanoma en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/j.1601-0825.2011.01841.x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.relation.issn 1601-0825


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