dc.contributor.author |
De Andrade, B. |
|
dc.contributor.author |
León, J. E. |
|
dc.contributor.author |
Carlos, R. |
|
dc.contributor.author |
Delgado-Azañero, W. |
|
dc.contributor.author |
Mosqueda-Taylor, A. |
|
dc.contributor.author |
Graner, E. |
|
dc.contributor.author |
de Almeida, O. |
|
dc.date.accessioned |
2022-01-18T19:26:53Z |
|
dc.date.available |
2022-01-18T19:26:53Z |
|
dc.date.issued |
2011 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/10986 |
|
dc.description.abstract |
The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions. Materials and Methods: Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas. Results: Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression. Conclusion: Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
Oral Diseases |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Humans |
en_US |
dc.subject |
protein expression |
en_US |
dc.subject |
human tissue |
en_US |
dc.subject |
Skin Neoplasms |
en_US |
dc.subject |
Tumor Markers, Biological |
en_US |
dc.subject |
Immunohistochemistry |
en_US |
dc.subject |
melanocytic nevus |
en_US |
dc.subject |
Melanoma |
en_US |
dc.subject |
Mouth Neoplasms |
en_US |
dc.subject |
Nevus, Pigmented |
en_US |
dc.subject |
Mouth Mucosa |
en_US |
dc.subject |
Antibodies |
en_US |
dc.subject |
Coloring Agents |
en_US |
dc.subject |
Nevus |
en_US |
dc.subject |
Fatty acid synthase |
en_US |
dc.subject |
Fatty Acid Synthetase Complex |
en_US |
dc.subject |
Melanocytes |
en_US |
dc.subject |
Melanocytic nevi |
en_US |
dc.subject |
Mouth |
en_US |
dc.subject |
Nevus, Intradermal |
en_US |
dc.title |
Expression of fatty acid synthase (FASN) in oral nevi and melanoma |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1111/j.1601-0825.2011.01841.x |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.14 |
|
dc.relation.issn |
1601-0825 |
|