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dc.contributor.author | De Andrade, B. | |
dc.contributor.author | León, J. E. | |
dc.contributor.author | Carlos, R. | |
dc.contributor.author | Delgado-Azañero, W. | |
dc.contributor.author | Mosqueda-Taylor, A. | |
dc.contributor.author | Graner, E. | |
dc.contributor.author | de Almeida, O. | |
dc.date.accessioned | 2022-01-18T19:26:53Z | |
dc.date.available | 2022-01-18T19:26:53Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/10986 | |
dc.description.abstract | The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions. Materials and Methods: Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas. Results: Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression. Conclusion: Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi. | en_US |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofseries | Oral Diseases | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Humans | en_US |
dc.subject | protein expression | en_US |
dc.subject | human tissue | en_US |
dc.subject | Skin Neoplasms | en_US |
dc.subject | Tumor Markers, Biological | en_US |
dc.subject | Immunohistochemistry | en_US |
dc.subject | melanocytic nevus | en_US |
dc.subject | Melanoma | en_US |
dc.subject | Mouth Neoplasms | en_US |
dc.subject | Nevus, Pigmented | en_US |
dc.subject | Mouth Mucosa | en_US |
dc.subject | Antibodies | en_US |
dc.subject | Coloring Agents | en_US |
dc.subject | Nevus | en_US |
dc.subject | Fatty acid synthase | en_US |
dc.subject | Fatty Acid Synthetase Complex | en_US |
dc.subject | Melanocytes | en_US |
dc.subject | Melanocytic nevi | en_US |
dc.subject | Mouth | en_US |
dc.subject | Nevus, Intradermal | en_US |
dc.title | Expression of fatty acid synthase (FASN) in oral nevi and melanoma | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1111/j.1601-0825.2011.01841.x | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.14 | |
dc.relation.issn | 1601-0825 |
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