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dc.contributor.author | Larsen, R.A. | |
dc.contributor.author | Bauer, M. | |
dc.contributor.author | Pitisuttithum, P. | |
dc.contributor.author | Sanchez, A. | |
dc.contributor.author | Tansuphaswadikul, S. | |
dc.contributor.author | Wuthiekanun, V. | |
dc.contributor.author | Peacock, S.J. | |
dc.contributor.author | Simpson, A.J.H. | |
dc.contributor.author | Fothergill, A.W. | |
dc.contributor.author | Rinaldi, M.G. | |
dc.contributor.author | Bustamante Rufino, Ana Beatriz | |
dc.contributor.author | Thomas, A.M. | |
dc.contributor.author | Altomstone, R. | |
dc.contributor.author | Day, N.P.J. | |
dc.contributor.author | White, N.J. | |
dc.date.accessioned | 2022-01-18T19:26:53Z | |
dc.date.available | 2022-01-18T19:26:53Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/10990 | |
dc.description.abstract | Testing of Cryptococcus neoformans for susceptibility to antifungal drugs by standard microtiter methods has not been shown to correlate with clinical outcomes. This report describes a modified quantitative broth macrodilution susceptibility method showing a correlation with both the patient's quantitative biological response in the cerebrospinal fluid (CSF) and the survival of 85 patients treated with amphotericin B (AMB). The Spearman rank correlation between the quantitative in vitro measure of susceptibility and the quantitative measure of the number of organisms in the patient's CSF was 0.37 (P < 0.01; 95% confidence interval [95% CI], 0.20, 0.60) for the first susceptibility test replicate and 0.46 (P < 0.001; 95% CI, 0.21, 0.62) for the second susceptibility test replicate. The median in vitro estimated response (defined as the fungal burden after AMB treatment) at 1.5 mg/liter AMB for patients alive at day 14 was 5 CFU (95% CI, 3, 8), compared to 57 CFU (95% CI, 4, 832) for those who died before day 14. These exploratory results suggest that patients whose isolates show a quantitative in vitro susceptibility response below 10 CFU/ml were more likely to survive beyond day 14. | en_US |
dc.language.iso | eng | |
dc.publisher | American Society for Microbiology | |
dc.relation.ispartofseries | Antimicrobial Agents and Chemotherapy | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Humans | en_US |
dc.subject | article | en_US |
dc.subject | controlled study | en_US |
dc.subject | major clinical study | en_US |
dc.subject | in vitro study | en_US |
dc.subject | priority journal | en_US |
dc.subject | quantitative analysis | en_US |
dc.subject | Treatment Outcome | en_US |
dc.subject | Survival Rate | en_US |
dc.subject | AIDS-Related Opportunistic Infections | en_US |
dc.subject | Microbial Sensitivity Tests | en_US |
dc.subject | cerebrospinal fluid | en_US |
dc.subject | broth dilution | en_US |
dc.subject | Antifungal Agents | en_US |
dc.subject | antifungal susceptibility | en_US |
dc.subject | Amphotericin B | en_US |
dc.subject | Cerebrospinal Fluid | en_US |
dc.subject | Colony Count, Microbial | en_US |
dc.subject | colony forming unit | en_US |
dc.subject | correlation coefficient | en_US |
dc.subject | Cryptococcus neoformans | en_US |
dc.subject | Meningitis, Cryptococcal | en_US |
dc.subject | survival | en_US |
dc.title | Correlation of susceptibility of Cryptococcus neoformans to amphotericin B with clinical outcome | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1128/AAC.00034-11 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.21 | |
dc.relation.issn | 1098-6596 |
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