Universidad Peruana Cayetano Heredia

Are increased Foxp3+ regulatory T cells responsible for immunosuppression during HTLV-1 infection? Case reports and review of the literature

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dc.contributor.author Barros, N.
dc.contributor.author Woll, F.
dc.contributor.author Watanabe, L.
dc.contributor.author Montes Delgado, Martin
dc.date.accessioned 2022-01-18T19:26:54Z
dc.date.available 2022-01-18T19:26:54Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11001
dc.description.abstract Research of human T lymphotropic virus type I (HTLV-1)-associated diseases is mostly focused on inflammatory and lymphoproliferative disorders. However, the immunosuppressive consequences of HTLV-1 infection are frequently ignored. In developing countries where exposure to parasitic and other tropical diseases is frequent, the burden of disease is significantly increased by opportunistic infections. Regulatory T cells (Tregs) are a CD4 T-cell subset capable of suppressing effector responses. During HTLV-1 infection, CD4+Foxp3+ cells are increased in HTLV-1-associated leukaemia/lymphoma (ATLL) as well as in non-leukaemic presentations. However, controversy exists regarding the actual regulatory function of these cells. In this report, we present two cases of HTLV-1 ATLL complicated by parasitic organisms and we provide a brief review of the literature regarding FoxP3+ regulatory T cells and their role as a possible mechanism for the immunosuppressive manifestations that take place during HTLV-1 infection. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries BMJ Case Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject disease association en_US
dc.subject case report en_US
dc.subject cyclophosphamide en_US
dc.subject diarrhea en_US
dc.subject flow cytometry en_US
dc.subject Human T cell leukemia virus 1 en_US
dc.subject skin biopsy en_US
dc.subject upregulation en_US
dc.subject strongyloidiasis en_US
dc.subject prednisone en_US
dc.subject anemia en_US
dc.subject anamnesis en_US
dc.subject Human T cell leukemia virus infection en_US
dc.subject ivermectin en_US
dc.subject Strongyloides stercoralis en_US
dc.subject lamivudine en_US
dc.subject immunohistochemistry en_US
dc.subject enzyme immunoassay en_US
dc.subject virus identification en_US
dc.subject weight reduction en_US
dc.subject alpha interferon en_US
dc.subject axillary lymph node en_US
dc.subject CD4+ T lymphocyte en_US
dc.subject cervical lymph node en_US
dc.subject doxorubicin en_US
dc.subject epigastric pain en_US
dc.subject epithelium hyperplasia en_US
dc.subject erythroderma en_US
dc.subject general condition deterioration en_US
dc.subject hospital acquired pneumonia en_US
dc.subject immune deficiency en_US
dc.subject inguinal lymph node en_US
dc.subject lymphadenopathy en_US
dc.subject lymphocytosis en_US
dc.subject microcytic anemia en_US
dc.subject pruritus en_US
dc.subject regulatory T lymphocyte en_US
dc.subject Sarcoptes scabiei en_US
dc.subject scabies en_US
dc.subject septic shock en_US
dc.subject skin exfoliation en_US
dc.subject T cell leukemia en_US
dc.subject tenofovir en_US
dc.subject tinea en_US
dc.subject transcription factor FOXP3 en_US
dc.subject vincristine en_US
dc.title Are increased Foxp3+ regulatory T cells responsible for immunosuppression during HTLV-1 infection? Case reports and review of the literature en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1136/bcr-2012-006574
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1757-790X


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