Universidad Peruana Cayetano Heredia

Effect of urbanisation on asthma, allergy and airways inflammation in a developing country setting

Mostrar el registro sencillo del ítem

dc.contributor.author Robinson, C.L.
dc.contributor.author Baumann, L.M.
dc.contributor.author Romero Rivero, Karina Maribel
dc.contributor.author Combe, J.M.
dc.contributor.author Gomez, A.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Cabrera, L.
dc.contributor.author Gonzalvez, G.
dc.contributor.author Hansel, N.N.
dc.contributor.author Wise, R.A.
dc.contributor.author Barnes, K.C.
dc.contributor.author Breysse, P.N.
dc.contributor.author Checkley, W.
dc.date.accessioned 2022-01-18T19:34:34Z
dc.date.available 2022-01-18T19:34:34Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11011
dc.description.abstract Background: Asthma is a growing public health problem in developing countries. However, few studies have studied the role of urbanisation in this phenomenon. It was hypothesised that children living in a peri-urban setting in Peru have higher rates of asthma and allergy than rural counterparts. Methods: 1441 adolescents aged 13-15 years were enrolled from two settings: a peri-urban shanty town in Lima (n=725) and 23 rural villages in Tumbes (n=716). Participants filled in questionnaires on asthma and allergy symptoms, environmental exposures and sociodemographics, and underwent spirometry, and exhaled nitric oxide (eNO) and allergy skin testing. Indoor particulate matter (PM) concentrations were measured in 170 households. Results: Lima adolescents had higher rates of lifetime wheezing (22% vs 10%), current asthma symptoms (12% vs 3%) and physician-diagnosed asthma (13% vs 2%; all p <0.001). Current rhinitis (23% vs 12%), eczema (12% vs 0.4%), atopy (56% vs 38%), personal history of cigarette smoking (7.4% vs 1.3%) and mean indoor PM (31 vs 13 μg/m3) were also higher in Lima (all p <0.001). The peri-urban environment of Lima was associated with a 2.6-fold greater odds (95% CI 1.3 to 5.3) of asthma in multivariable regression. Forced expiratory volumes were higher and FEV1/FVC (forced expiratory volume in 1 s/forced vital capacity) ratios were lower in Lima (all p <0.001). Higher eNO values in Lima (p <0.001) were attributable to higher rates of asthma and atopy. Conclusions: Peri-urban adolescents had more asthma, atopy and airways inflammation and were exposed to more indoor pollution. The findings provide evidence of the risks posed to lung health by peri-urban environments in developing countries. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Thorax
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject controlled study en_US
dc.subject urban population en_US
dc.subject environmental exposure en_US
dc.subject forced vital capacity en_US
dc.subject urban area en_US
dc.subject cigarette smoking en_US
dc.subject nitric oxide en_US
dc.subject asthma en_US
dc.subject indoor air pollution en_US
dc.subject allergy test en_US
dc.subject bronchodilating agent en_US
dc.subject particulate matter en_US
dc.subject spirometry en_US
dc.subject corticosteroid en_US
dc.subject wheezing en_US
dc.subject forced expiratory volume en_US
dc.subject respiratory tract inflammation en_US
dc.subject urbanization en_US
dc.subject atopy en_US
dc.subject respiratory tract parameters en_US
dc.subject allergy en_US
dc.subject eczema en_US
dc.subject exhaled nitric oxide en_US
dc.subject rhinitis en_US
dc.title Effect of urbanisation on asthma, allergy and airways inflammation in a developing country setting en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/thx.2011.158956
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1468-3296


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas