Universidad Peruana Cayetano Heredia

Clinical studies of lactoferrin in children

Mostrar el registro sencillo del ítem

dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Pezo, Alonso
dc.contributor.author Cruz, Karen
dc.contributor.author Chea-Woo, Elsa
dc.contributor.author Cleary, Thomas G.
dc.date.accessioned 2022-01-18T19:34:34Z
dc.date.available 2022-01-18T19:34:34Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11013
dc.description.abstract Much has been learned in recent years about the mechanisms by which breastfeeding improves child health and survival. However, there has been little progress in using these insights to improve pediatric care. The aim of this study was to review all clinical studies of lactoferrin (LF) in children in an effort to determine which interventions may improve pediatric care or require further research. We conducted a systematic and critical review of published literature and found 19 clinical studies that have used human or bovine LF for different outcomes: iron metabolisms and anemia (6 studies), fecal flora (5 studies), enteric infections (3 studies), common pediatric illnesses (1 study), immunomodulation (3 studies), and neonatal sepsis (1 study). Although the efficacies have varied in each trial, the main finding of all published studies is the safety of the intervention. Protection against enteric infections and neonatal sepsis are the most likely biologically relevant activities of LF in children. Future studies on neonatal sepsis should answer critically important questions. If the data from these sepsis studies are proven to be correct, it will profoundly affect the treatment of low birth weight neonates and will aid in the reduction of child mortality worldwide. en_US
dc.description.abstract Au cours des dernières années, on en a appris beaucoup sur les mécanismes par lesquels l’allaitement améliore la santé et la survie de l’enfant. Cependant, il y a eu peu de progrès quant à l’utilisation de ces connaissances pour améliorer les soins pédiatriques. Cette étude vise à passer en revue toutes les études cliniques portant sur la lactoferrine chez les enfants, afin de déterminer quelles sont les interventions qui peuvent améliorer les soins pédiatriques ou nécessitent des recherches plus approfondies. Nous avons réalisé une revue systématique et critique de la littérature publiée et nous avons trouvé 19 études cliniques dans lesquelles la lactoferrine bovine ou humaine avait été utilisée à différentes fins : le métabolisme du fer et l’anémie (6 études), la flore fécale (5 études), les infections entériques (3 études), les maladies pédiatriques courantes (1 étude), l’immunomodulation (3 études) et la sepsie néonatale (1 étude). Malgré une efficacité variable selon les essais, la principale conclusion tirée de toutes ces études publiées était la sécurité de l’intervention. La protection contre les infections entériques et la sepsie néonatale constituent probablement les activités les plus pertinentes biologiquement de la lactoferrine chez les enfants. Si les données découlant des études portant sur la sepsie s’avèrent justes, cela affectera profondément le traitement des nouveaux-nés de faible poids et contribuera à la réduction de la mortalité infantile dans le monde. fr_FR
dc.language.iso eng
dc.publisher NRC Research Press
dc.relation.ispartofseries Biochemistry and Cell Biology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject placebo en_US
dc.subject Infant, Newborn en_US
dc.subject Feces en_US
dc.subject Clinical trial en_US
dc.subject birth weight en_US
dc.subject treatment outcome en_US
dc.subject childhood disease en_US
dc.subject anemia en_US
dc.subject systematic review en_US
dc.subject intestine infection en_US
dc.subject Bovinae en_US
dc.subject Lactoferrin en_US
dc.subject Biochemistry en_US
dc.subject Breastfeeding en_US
dc.subject Cell culture en_US
dc.subject child care en_US
dc.subject Child Health Services en_US
dc.subject Child mortality en_US
dc.subject Children en_US
dc.subject Clinical studies|Clinical Trials as Topic en_US
dc.subject Communicable Diseases en_US
dc.subject Critical review en_US
dc.subject feces microflora en_US
dc.subject Gastrointestinal Diseases en_US
dc.subject Immunomodulation en_US
dc.subject Iron metabolism en_US
dc.subject Iron Metabolism Disorders en_US
dc.subject Low birth weights en_US
dc.subject newborn sepsis en_US
dc.subject Pediatrics en_US
dc.subject Sepsis en_US
dc.title Clinical studies of lactoferrin in children en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1139/o11-087
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.relation.issn 1208-6002


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas