Universidad Peruana Cayetano Heredia

Single parenchymal brain cysticercus: Relationship between age of patients and evolutive stage of parasites

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dc.contributor.author Del Brutto, V.J.
dc.contributor.author Del Brutto, O.H.
dc.contributor.author Ochoa, E.
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2022-01-18T19:34:35Z
dc.date.available 2022-01-18T19:34:35Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11029
dc.description.abstract Background: A recent hypothesis suggested that in many cases cysticercal granulomas represent recently established Taenia solium metacestodes rapidly destroyed by the host's immune system. Here, we attempted to determine whether patients with cysticercal granulomas are younger than those with other forms of parenchymal brain cysticercosis. Methods: Series of 185 patients with single parenchymal brain cysticercus, classified according to the stage of the parasite at the moment of diagnosis in cysts without inflammation, cysts with inflammation, granular lesions, and calcifications. We correlated the age of the patients with the parasite evolutive stage. Results: Patients with cysticercus granulomas were significantly younger than those with vesicular cysts (17.7±12.9 versus 36.8±15.1 years, P<0.005) or calcifications (17.7±12.9 versus 40.8±19.7 years, P<0.0001). There was also a non-significant trend for patients with granulomas to be younger than those with coloidal cysts (17.7±12.9 versus 26.7±15.6 years, P=0.367). Conclusions: Results from this study argued against the classical hypothesis that granulomas are the end result from long-established vesicular cysts destroyed by the host's immune system. Vesicular (viable) cysticerci must be treated with cysticidal drugs as it is unlikely that they will be spontaneously destroyed. en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Neurological Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Animals en_US
dc.subject Age Factors en_US
dc.subject inflammation en_US
dc.subject calcification en_US
dc.subject disease course en_US
dc.subject host parasite interaction en_US
dc.subject Taenia solium en_US
dc.subject Cysticercosis en_US
dc.subject Neurocysticercosis en_US
dc.subject Biological Evolution en_US
dc.subject granuloma en_US
dc.subject immune system en_US
dc.subject Parasites en_US
dc.subject Cysticercal granuloma en_US
dc.subject cysticercoid en_US
dc.subject Taenia solium metacestode en_US
dc.title Single parenchymal brain cysticercus: Relationship between age of patients and evolutive stage of parasites en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1179/1743132812Y.0000000100
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn 1743-1328


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