Universidad Peruana Cayetano Heredia

Regulation of hepcidin expression at high altitude

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dc.contributor.author Talbot, N.P.
dc.contributor.author Lakhal, S.
dc.contributor.author Smith, T.G.
dc.contributor.author Privat, C.
dc.contributor.author Nickol, A.H.
dc.contributor.author Rivera Chira, Maria Concepcion
dc.contributor.author León-Velarde, Fabiola
dc.contributor.author Dorrington, K.L.
dc.contributor.author Mole, D.R.
dc.contributor.author Robbins, P.A.
dc.date.accessioned 2022-01-18T19:34:35Z
dc.date.available 2022-01-18T19:34:35Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11033
dc.description.abstract Enhanced erythropoietic drive and iron deficiency both influence iron homeostasis through the suppression of the iron regulatory hormone hepcidin. Hypoxia also suppresses hepcidin through a mechanism that is unknown. We measured iron indices and plasma hepcidin levels in healthy volunteers during a 7-day sojourn to high altitude (4340 m above sea level), with and without prior intravenous iron loading.Without prior iron loading, a rapid reduction in plasma hepcidin was observed that was almost complete by the second day at altitude. This occurred before any index of iron availability had changed. Prior iron loading delayed the decrease in hepcidin until after the transferrin saturation, but not the ferritin concentration, had normalized. We conclude that hepcidin suppression by the hypoxia of high altitude is not driven by a reduction in iron stores. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Blood
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject controlled study en_US
dc.subject normal |altitude en_US
dc.subject hypoxia en_US
dc.subject human experiment en_US
dc.subject iron en_US
dc.subject hepcidin en_US
dc.subject hormonal regulation en_US
dc.subject hormone blood level en_US
dc.subject iron blood level en_US
dc.subject transferrin en_US
dc.subject transferrin blood level en_US
dc.title Regulation of hepcidin expression at high altitude en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1182/blood-2011-03-341776
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.06
dc.relation.issn 1528-0020


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