Universidad Peruana Cayetano Heredia

Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in tuberculosis

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dc.contributor.author Elkington, P.T.
dc.contributor.author Ugarte Gil, Cesar Augusto
dc.contributor.author Friedland, J.S.
dc.date.accessioned 2022-01-18T19:34:35Z
dc.date.available 2022-01-18T19:34:35Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11034
dc.description.abstract Tuberculosis (TB) remains a global health pandemic. Infection is spread by the aerosol route and Mycobacterium tuberculosis must drive lung destruction to be transmitted to new hosts. Such inflammatory tissue damage is responsible for morbidity and mortality in patients. The underlying mechanisms of matrix destruction in TB remain poorly understood but consideration of the lung extracellular matrix predicts that matrix metalloproteinases (MMPs) will play a central role, owing to their unique ability to degrade fibrillar collagens and other matrix components. Since we proposed the concept of a matrix degrading phenotype in TB a decade ago, diverse data implicating MMPs as key mediators in TB pathology have accumulated. We review the lines of investigation that have indicated a critical role for MMPs in TB pathogenesis, consider regulatory pathways driving MMPs and propose that inhibition of MMP activity is a realistic goal as adjunctive therapy to limit immunopathology in TB. ERS . en_US
dc.language.iso eng
dc.publisher European Respiratory Society
dc.relation.ispartofseries European Respiratory Journal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject pathology en_US
dc.subject genetics en_US
dc.subject metabolism en_US
dc.subject phenotype en_US
dc.subject protein expression en_US
dc.subject pathogenicity en_US
dc.subject morbidity en_US
dc.subject review en_US
dc.subject mortality en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Tuberculosis en_US
dc.subject enzymology en_US
dc.subject interstitial collagenase en_US
dc.subject Monocytes en_US
dc.subject lung tuberculosis en_US
dc.subject Tuberculosis, Pulmonary en_US
dc.subject doxycycline en_US
dc.subject immunoglobulin G en_US
dc.subject enzyme activity en_US
dc.subject radiography en_US
dc.subject BCG vaccine en_US
dc.subject pathogenesis en_US
dc.subject enzyme inhibition en_US
dc.subject immune reconstitution inflammatory syndrome en_US
dc.subject dexamethasone en_US
dc.subject prediction en_US
dc.subject Lung en_US
dc.subject drug antagonism en_US
dc.subject bacterial transmission en_US
dc.subject CD14 antigen en_US
dc.subject collagen fibril en_US
dc.subject drug targeting en_US
dc.subject enzyme degradation en_US
dc.subject Extracellular Matrix en_US
dc.subject gelatinase A en_US
dc.subject gelatinase B en_US
dc.subject Gene Expression Profiling en_US
dc.subject Immunopathology en_US
dc.subject matrilysin en_US
dc.subject matrix metalloproteinase inhibitor en_US
dc.subject Matrix Metalloproteinases en_US
dc.subject neutrophil collagenase en_US
dc.subject stromelysin en_US
dc.subject stromelysin 2 en_US
dc.subject toll like receptor en_US
dc.subject tuberculous meningitis en_US
dc.title Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in tuberculosis en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1183/09031936.00015411
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1399-3003


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