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Using GRADE methodology for the development of public health guidelines for the prevention and treatment of HIV and other STIs among men who have sex with men and transgender people

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dc.contributor.author Akl, E.A.
dc.contributor.author Kennedy, C.
dc.contributor.author Konda, K.
dc.contributor.author Caceres Palacios, Carlos Fernando
dc.contributor.author Horvath, T.
dc.contributor.author Ayala, G.
dc.contributor.author Doupe, A.
dc.contributor.author Gerbase, A.
dc.contributor.author Wiysonge, C.S.
dc.contributor.author Segura, E.R.
dc.contributor.author Schünemann, H.J.
dc.contributor.author Lo, Y.-R.
dc.date.accessioned 2022-01-18T19:34:35Z
dc.date.available 2022-01-18T19:34:35Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11039
dc.description.abstract Background: The World Health Organization (WHO) Department of HIV/AIDS led the development of public health guidelines for delivering an evidence-based, essential package of interventions for the prevention and treatment of HIV and other sexually transmitted infections (STIs) among men who have sex with men (MSM) and transgender people in the health sector in low- and middle-income countries. The objective of this paper is to review the methodological challenges faced and solutions applied during the development of the guidelines. Methods. The development of the guidelines followed the WHO guideline development process, which utilizes the GRADE approach. We identified, categorized and labeled the challenges identified in the guidelines development process and described the solutions through an interactive process of in-person and electronic communication. Results: We describe how we dealt with the following challenges: (1) heterogeneous and complex interventions; (2) paucity of trial data; (3) selecting outcomes of interest; (4) using indirect evidence; (5) integrating values and preferences; (6) considering resource use; (7) addressing social and legal barriers; (8) wording of recommendations; and (9) developing global guidelines. Conclusion: We were able to successfully apply the GRADE approach for developing recommendations for public health interventions. Applying the general principles of the approach while carefully considering specific challenges can enhance both the process and the outcome of guideline development. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Public Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject review en_US
dc.subject HIV Infections en_US
dc.subject Homosexuality, Male en_US
dc.subject Transgendered Persons en_US
dc.subject Human immunodeficiency virus infection en_US
dc.subject methodology en_US
dc.subject Sexually Transmitted Diseases en_US
dc.subject transsexualism en_US
dc.subject developing country en_US
dc.subject World Health Organization en_US
dc.subject Developing Countries en_US
dc.subject Practice Guidelines as Topic en_US
dc.subject Evidence-Based Medicine en_US
dc.title Using GRADE methodology for the development of public health guidelines for the prevention and treatment of HIV and other STIs among men who have sex with men and transgender people en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1186/1471-2458-12-386
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1471-2458


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